Senior Scientist , Early Target Generation

Senior Scientist I, Early Target Generation

• Full-time
• Salary Min: 96500
• Salary Max: 183500
• Workday Global Grade: 17
• Compensation: USD 96500 - USD 183500 - yearly

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us  .

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Are you passionate about making a difference in patients’ lives?

Are you interestedinbeing part of a team that helps craft innovative solutionstocomplex problems? Abb Vie's Discovery Biotherapeutics and Genetic Medicine (BGM) invites you to join us as aSenior

Scientist Iin the Exploratory Target Generation group of Protein Sciencesteamat the Cambridge Research Center (CRC) site based in Cambridge, MA.This position offers the unique opportunity to participate in early program design and strategy, with a strong impact on our future pipeline.

As a Senior Scientist you willberesponsible forexpressionof complexproteinantigens(cytokines, extracellular domains, membrane proteins, etc.)supporting exploratory programs in our Immunology and Neuroscience therapeutic areas.

The ideal candidate will have a strong protein biochemistry background,particularly in mammalian protein expression systems, and demonstrate a proven track record of innovative problem solvingas acontributor incross-functional collaborations.

Strong verbal and written communication skills are required for effectively presenting scientific concepts and results to both scientific and non-scientific leaders. A significant research background, evidenced by a track record of publications, presentations, and scientific accomplishments, is highly desirable.

Strategically engaged at the early exploratory stages of target selection within the Immunology and Neuroscience therapeutic areas

Recombinantprotein expressionofantigensand cytokines supporting exploratory Immunology and Neuroscience therapeutic areas

Innovatively design and produce soluble and membrane protein targets with enhanced stability for functional studies and antibody discovery

Collaboration with Immunology and Neuroscience colleagues asrepresentativeof Protein Sciences,fostering the generation of innovative ideas and solutions

Contribute to scientific excellence through dedication to multiple projects simultaneously,in a fast-paced, multi-disciplinary environment

Demonstration of strong organizational and record keeping skills,ensuring timely delivery of requested material

Clearly and effectively explain research findings and strategies,prioritizing transparency

Collaborate with protein vendors and Contract Research Organizations (CROs) to secure,produce, and evaluate high-quality antigens

Cultivate innovative problem-solving by generating original technical ideas and responding to scientific, regulatory, and competitive developments

Maintain a strong knowledge of relevant publications pertaining totechnologicaladvancements, with an eye towards improving our workflows

Ph.D., M.S. or  Biochemistry, Molecular and Cell Biology or related disciplines with typically 0-4 (Ph.D), 8-10 (M.S.), or 10-12+ (B.S.) years of experience

Hands-on experience with mammalian suspension cell culture(HEK
293 and CHO preferred) transient transfection, harvest and expression profiling is required

Strong molecular biology skillsand experience with sequencing toolsand construct designisrequired(Geneious,Genedata)

Experienceusingand interpreting standard protein analytical techniques (SDS-PAGE, Western blotting,BCA assays, endotoxin readings, size exclusion chromatography) is required

Experience with a broad spectrum of protein purification techniques (affinity, ion exchange, size exclusion chromatography,etc), preferably using AKTA instrumentation is a plus

Experience applying AI/ML workflows toimprove laboratory workflows is desired

Expertise in navigating and managing relationships with different protein vendors and CROs, ensuring alignment with project goals and timelines, is a plus

Experience using

Gene Data Biologics  is a plus

Strong Immunology and/or Neuroscience background is a plus

Experience inprotein expression from e. coli is a plus

Proven research excellence demonstrated through a strong…