Process Development Scientist – Reactors & Chromatography

Pay Rate: Up to $56 per hour or about $114,000

Schedule: Monday–Friday, standard business hours; no weekend work

The Process Sciences team is seeking a hands‑on Scientist to support the development, characterization, optimization, and scale‑up of manufacturing processes for oligonucleotide drug substances. This individual will apply principles of mass transfer, reaction engineering, and solid‑liquid interactions to an emerging solid‑phase synthesis platform.

The strongest candidates will have practical experience with packed-bed reactor systems, large-scale chromatography, and process scale‑up
. Direct oligonucleotide experience is preferred but not required. Scientists and engineers with relevant experience in chromatography columns, catalytic reactors, polymer or resin systems, peptide synthesis, fluidized beds, or similar solid‑liquid processes are encouraged to apply.

This laboratory‑based position is fully onsite at the company’s Kendall Square offices in Cambridge, Massachusetts.

• Contribute to the development, optimization, characterization, and scale‑up of oligonucleotide manufacturing processes.
• Design and execute laboratory studies involving packed‑bed reactors, chromatography columns, resins, solid supports, and related solid‑liquid systems.
• Apply mass‑transfer and reaction‑engineering principles to understand and improve process performance.
• Support process and product characterization for small‑molecule and oligonucleotide active pharmaceutical ingredients.
• Troubleshoot process failures, identify root causes, and recommend technically sound solutions.
• Support the transfer of processes from laboratory development to larger‑scale and manufacturing environments.
• Contribute to the management and optimization of internal and external manufacturing processes.
• Author and review technical protocols, development reports, study summaries, and process‑characterization documentation.
• Prepare, edit, and review manufacturing documentation in accordance with applicable procedures and regulatory requirements.
• Collaborate with Analytical Development, Manufacturing, Quality Assurance, Quality Control, and external CMO/CRO partners on process transfer and optimization activities.
• Analyze experimental results, communicate conclusions, and present technical findings to internal and external scientific teams.
• Participate in strategic technical discussions related to process development, scale‑up, and manufacturing readiness.

• Master’s degree in chemistry, chemical engineering, biochemical engineering, or a closely related scientific or engineering discipline.
• Hands‑on experience with packed‑bed reactor systems or closely related solid‑liquid processing equipment.
• Experience with large‑scale chromatography
  , including chromatography column operation beyond routine MPLC use.
• Strong understanding of mass transfer, reaction engineering, fluid flow, and interactions among fluids, reagents, and solid particles
  .
• Demonstrated experience developing, characterizing, optimizing, or scaling practical manufacturing processes.
• Experience troubleshooting process failures and translating laboratory findings into process improvements.
• Experience working with chromatography resins, polymer systems, solid supports, catalysts, or comparable materials.
• Ability to author clear technical protocols and reports and present scientific findings to technical audiences.
• Strong organizational, communication, operational‑execution, and problem‑solving skills.
• Ability to work effectively in a fast‑paced, deadline‑driven, cross‑functional laboratory environment.

• Three or more years of process research and development experience within the pharmaceutical,…