Scientist I​/II

Position Title: Scientist I/II
Reports To: Director, Discovery
Location: Watertown, MA Join the adventure!

CAMP4 is seeking a highly motivated Scientist to join our Discovery team and contribute to the advancement of CNS programs from target selection through candidate nomination. This is an excellent opportunity for a recent PhD graduate with a strong background in neuroscience or a related discipline who is interested in applying functional neuroscience approaches to drug discovery. A primary responsibility of this role will be to develop and establish functional and phenotypic assays in human iPSC-derived neuronal models to support target validation and characterize the activity of candidate ASOs.

The successful candidate will apply approaches such as multielectrode array (MEA), calcium imaging, and high-content imaging to characterize disease-relevant neuronal phenotypes and to evaluate rescue by candidate ASO. The Scientist will work closely with members of the Discovery team as well as cross-functional colleagues in Platform, Chemistry, Preclinical and Data Science. We are looking for a curious, rigorous, and collaborative Scientist who enjoys developing new experimental approaches and translating biological questions into robust cellular assays.

• Develop, optimize, and implement functional and phenotypic assays in human iPSC-derived neurons, including multielectrode array (MEA), calcium imaging, and high-content imaging.
• Establish disease-relevant neuronal phenotypes in patient iPSC-derived neurons and evaluate functional responses to candidate ASOs.
• Design and execute experiments supporting target validation though candidate selection across CNS discovery programs.
• Develop cellular and biochemical assays to assess target engagement and downstream biological effects of ASOs.
• Analyze, interpret, and communicate experimental results to project teams and broader scientific audiences.
• Collaborate with cross-functional scientists to integrate functional assay results with molecular, genomic, and pharmacological data to drive project advancement to key go/no-go decisions.
• Maintain accurate and detailed experimental records to support regulatory documentation of candidate ASOs.

• PhD in neuroscience, molecular biology, cell biology, or a related discipline with 0-3 years of post-degree experience.

• Hands-on experience with neuronal functional or phenotypic assays, with experience in one or more of the following strongly preferred: multielectrode array (MEA), calcium imaging, and high-content imaging.
• Strong mammalian cell culture skills; experience with human iPSC-derived neurons, primary neurons, or other neuronal culture systems is highly desirable.
• Experience with immunofluorescence, microscopy, and quantitative analysis of cellular phenotypes.
• Ability to independently design, execute, troubleshoot, and interpret experiments.
• Strong quantitative and analytical skills to generate decision-enabling data packages.
• Excellent organizational and communication skills with the ability to work effectively in a fast-paced, collaborative, and multidisciplinary environment.
• Scientific curiosity, rigor, attention to detail, and enthusiasm for translating fundamental neuroscience into therapeutic discovery.

At CAMP4 Therapeutics, we offer a competitive and thoughtfully designed total rewards program. The anticipated salary range for this role is $125,000 - $150,000. Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. In addition to base salary, employees are eligible to receive an annual bonus and equity incentive opportunities.

• medical, dental, and vision insurance
• life and disability coverage
• paid parental leave
• a 401(k) plan with company contribution
• Employee Stock Purchase Program, Trek Time (flexible time off)
• tuition assistance
• and additional perks that support your well-being and professional growth.

CAMP4 is developing disease-modifying treatments for a broad range of genetic diseases where amplifying healthy protein may offer therapeutic benefits. Our approach amplifies mRNA by harnessing a fundamental mechanism of how genes are controlled. To amplify mRNA, our therapeutic ASO drug candidates target regulatory RNAs (regRNAs), which act locally on transcription factors and are the master…