Research Scientist I or II, Oligonucleotide Chemistry

Summary

Job Title:

Research Scientist I or II, Oligonucleotide Chemistry

Job Title:

Research Scientist I or II, Oligonucleotide Chemistry

Location:

Cambridge, USA

Relocation Support:
This role is based in Cambridge, USA. Novartis is unable to offer relocation support: please only apply if accessible.

Imagine helping shape the future of RNA-based medicines through hands‑on scientific innovation. At Novartis, we're pushing the boundaries of xRNA therapeutics to address some of the world's most challenging diseases, and we're looking for a talented scientist to join us on that journey. As a Research Scientist in Oligonucleotide Chemistry, you'll play a key role in synthesizing, optimizing, and characterizing therapeutic oligonucleotides while collaborating with a diverse team of experts across discovery and development.

This is an exciting opportunity to apply your scientific expertise, grow your technical skills, and contribute directly to groundbreaking therapies that have the potential to transform patients' lives.

Key Responsibilities

• Execute solid-phase synthesis of research-scale oligonucleotides using advanced automated DNA and RNA synthesizers.
• Purify, desalt, and characterize oligonucleotides using chromatographic and mass spectrometry techniques.
• Develop and optimize synthesis, purification, and analytical methods to improve performance and reproducibility.
• Operate, maintain, and troubleshoot laboratory instrumentation supporting oligonucleotide production and analysis.
• Prepare and maintain standard operating procedures to support high-quality and consistent laboratory practices.
• Organize, analyze, and document experimental results using electronic laboratory notebook systems.
• Contribute effectively within a collaborative, fast-paced research environment focused on therapeutic innovation.

• Bachelor of Science or Master of Science in Chemistry or a related scientific discipline.
• One to three years of laboratory experience in academic or industrial research environments.
• Hands‑on experience with automated solid‑phase synthesizers and therapeutic oligonucleotide synthesis workflows.
• Proficiency in oligonucleotide purification, characterization, and analysis using chromatography and mass spectrometry techniques.
• Understanding of RNA therapeutics and their application in biological systems.
• Strong collaboration, adaptability, and self‑motivation in a fast-paced scientific environment.

• Experience supporting oligonucleotide process development, optimization, or technology innovation initiatives.
• Excellent scientific communication skills with the ability to present findings to multidisciplinary teams.

At Novartis, we're committed to reimagining medicine together - and rewarding the people who make it happen.

The rewards of being part of our team go far beyond base pay and incentives. We also offer a variety of competitive benefits in kind to help you thrive personally and professionally, such as insurance plans, retirement plans, wellbeing resources and global recognition programs. In addition, we provide flexible and hybrid working options, where possible, and a minimum of 14 weeks paid parental leave.

• US:66,800. USD Annual

The salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically.

In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters. Further details will be provided during the application process.

Pay equity is a fundamental principle of our employment policy and…