Principal Scientist, DMPK

The successful candidate will be part of a team responsible for understanding the disposition mechanisms and pharmacokinetic/pharmacodynamic (PK/PD) relationships of oligonucleotide therapeutics and other emerging modalities. The candidate will work closely with colleagues across Research and Development as a Principal Scientist within Drug Metabolism and Pharmacokinetics (DMPK), providing scientific leadership and strategic guidance to advance programs from discovery through clinical development.

Work arrangement: This is an in-office position based in Cambridge, Massachusetts, requiring regular on-site collaboration with cross-functional teams.

• Develop and implement DMPK strategies to support discovery, candidate selection, translational research, and clinical development of oligonucleotide therapeutics and other drug modalities.
• Design, execute, interpret, and communicate DMPK studies to characterize absorption, distribution, metabolism, excretion (ADME), PK/PD relationships, and translational pharmacology.
• Collaborate closely with Research scientists to optimize tissue delivery, pharmacology, and candidate selection for advancement into development.
• Partner with Toxicology, Clinical Pharmacology, Bioanalytical Sciences, Regulatory Affairs, and Project Leadership teams to integrate PK, PD, efficacy, safety, and biomarker data and inform development decisions.
• Apply quantitative approaches, including modeling and simulation, to support dose prediction, translation, and development strategy.
• Represent DMPK as a key scientific contributor on multidisciplinary, matrixed project teams and participate in program and governance discussions.
• Lead or contribute to the preparation of DMPK reports, regulatory submission content, and responses supporting CTA, IND, NDA, and other global health authority filings.
• Provide scientific mentorship and technical guidance to junior scientists and contribute to building DMPK capabilities across the organization.
• Effectively manage multiple programs, deliverables, and priorities in a fast-paced environment while maintaining high-quality scientific output.
• Present scientific findings and recommendations clearly and effectively to project teams, senior management, external collaborators, and regulatory agencies, as appropriate.

• Ph.D. in pharmacokinetics, pharmaceutical sciences, pharmacology, biomedical engineering, or a related scientific discipline.
• Minimum of 6+ years of relevant industry experience in pharmaceutical or biotechnology drug discovery and development.
• Strong understanding of ADME, pharmacokinetics, PK/PD principles, and translational pharmacology.
• Demonstrated experience developing and executing DMPK strategies for discovery- and/or development-stage programs.
• Direct experience contributing to CTA and/or IND filings, including preparation or review of relevant regulatory submission content.
• Proven ability to work effectively and influence outcomes in highly matrixed, multidisciplinary teams.
• Strong quantitative, analytical, and problem-solving skills, with experience integrating diverse datasets to drive decision-making.
• Excellent written, verbal, presentation, and interpersonal communication skills, with the ability to communicate complex scientific concepts to diverse audiences.
• Demonstrated ability to multitask, manage multiple projects simultaneously, meet timelines, and adapt to changing priorities.

• Experience with oligonucleotide therapeutics, RNAi, ASO, antibody-oligonucleotide conjugates, peptides, antibodies, or other advanced therapeutic modalities.
• Experience with modeling and simulation approaches, including population PK, PBPK, mechanistic PK/PD, or translational modeling.
• Experience supporting regulatory interactions and responding to health authority questions.
• Familiarity with biomarkers, translational medicine, and quantitative pharmacology approaches.

#LI-JR1

$ - $

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and…