Scientist, Early Formulation

Scientist, Early Formulation Department Protein  Structure & Biochemistry, Vx Discovery Technology Location Cambridge park  Drive, Cambridge, MA, United States (on-site)
About GSKAt GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, focusing our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success.

We’re uniting science, technology, and talent to get ahead of disease together.

Position Summary :

The Scientist, Early Formulation will be a key member of the Early Formulation team in Cambridge, MA, developing fit-for-purpose vaccine formulations that support projects for preclinical studies and generating in vitro assessment insights that guide antigen design, lead selection, and optimization. This hands-on, laboratory-based role focuses on designing and executing formulation and stability studies, characterizing physicochemical properties, and generating in vitro and in vivo assessment data that inform antigen design, lead selection, and portfolio decision-making across multiple vaccine modalities.

Responsibilities:

Design, prepare and test vaccine formulations at bench scale to support progression of key pipeline projects in Early Formulation and the broader Vaccine Discovery Technology projects.

Support timely screening and comparison of different vaccine modalities (e.g., adjuvanted protein, mRNA-LNP, VLPs, polysaccharide vaccines) for in vitro and in vivo evaluations, contributing data that enables candidate ranking, selection and optimization.

Build, maintain and operate high-throughput formulation and screening processes across multiple modalities, applying design–build–test–learn workflows to accelerate vaccine discovery and portfolio decision-making.

Characterize physicochemical properties and relevant critical quality attributes using analytical methods such as particle size analysis, pH and viscosity measurement, single-particle measurements, chromatography and thermal analysis.

Design and execute stability studies and compatibility assessments under fit-for-purpose formulation conditions, interpret data, and provide clear recommendations to project teams regarding candidate robustness and formulation risks.

Maintain accurate, high-quality laboratory records (electronic and/or paper notebooks), prepare study reports, and present data and scientific insights to project teams and stakeholders in a clear, structured manner.

Conform to Environmental Health and Safety (EHS) rules and regulations, maintaining the formulation laboratory space in an organized, safe and inspection-ready condition.

Troubleshoot experiments, improve methods, and contribute to the development and refinement of standard operating procedures and standardized workflows that enhance reproducibility and throughput.

Demonstrate strong ownership and accountability for delivery of data and materials to project milestones, working proactively with team members to keep tasks on track and resolve issues.

Actively contribute to a collaborative, inclusive and high-performing team culture, showing excellent interpersonal skills, a patient and approachable demeanor, and clear verbal and written communication.

Basic Qualifications :

BS (+8 years), MS (+4 years) or PhD (+0 years) in pharmaceutical sciences, chemical engineering, biochemistry, formulation science or a closely related discipline.

Laboratory experience…