Scientist, Throughput Antibody Production

Biologics Engineering (BE) is a large, global organization with teams in Cambridge, UK;
Gaithersburg, MD; and Cambridge, MA. We discover and optimize next-generation biologics for therapeutic areas including oncology, respiratory and immunology, and cardiovascular, renal and metabolic diseases. Our Cambridge, MA team is building an innovation center and lighthouse laboratory that combines scientific expertise, high-throughput automation, robotics, and digital orchestration to expand what is possible in biologics discovery.

Through close collaboration across disciplines and geographies, we deliver high-quality therapeutic molecules that advance the R&D pipeline and address unmet patient needs.

We are seeking a highly organized, detail-oriented Scientist to join our High-Throughput Production (HTP) team in Cambridge, MA. The successful candidate will use an advanced, integrated robotics laboratory to routinely produce, purify, and quality-control hundreds of antibodies and antibody-like therapeutic molecules each week in support of R&D pipeline programs. Working within validated, end-to-end automated workflows designed to enable near-lights-out production, this role is accountable for reliable execution, complete documentation, instrument and material readiness, and timely delivery of high-quality samples and data.

Success requires hands‑on high-throughput production experience, fundamental knowledge of protein expression and purification, disciplined adherence to detailed SOPs and instructions, exceptional attention to detail, and a collaborative team‑first mindset. The primary focus is consistent operational delivery; the Scientist will also identify and communicate deviations, risks, and practical opportunities to improve workflow reliability.

• Execute scheduled, high-throughput transient expression, purification, and sample-preparation campaigns for antibodies, multispecifics, and recombinant fragments, routinely supporting delivery of hundreds of molecules per week across R&D pipeline programs.
• Operate liquid handlers and integrated robotics platforms, including Hamilton and Lynx systems and Cellario orchestration software, using approved methods; complete deck setup, barcode and consumable checks, run monitoring, recovery steps, and basic troubleshooting in accordance with SOPs.
• Prepare media, reagents, plates, and consumables; culture CHO and HEK
  293 cells; perform aseptic transient transfections; harvest via filtration or centrifugation in accordance with SOPs.
• Perform routine production and QC testing according to established methods, including concentration, purity, identity, and other fit-for-purpose biochemical, biophysical, or functional measurements; assess results against acceptance criteria and compile complete, traceable data packages for project teams.
• Track samples, inventory, and metadata in laboratory logistics/LIMS software to maintain chain-of-custody and ensure timely delivery and data completeness.
• Maintain automation and analytical instrumentation readiness through preventive maintenance, calibrations, and upkeep of equipment logs; coordinate vendor service when required.
• Coordinate daily work with HTP colleagues and cross‑functional partners to meet weekly throughput, quality, and turnaround targets; communicate status, dependencies, deviations, and delivery risks clearly and promptly.
• Follow detailed SOPs, work instructions, and production schedules precisely; recognize and elevate departures from expected performance, and contribute practical observations that strengthen process robustness and operational consistency.
• Engage with AI/ML and automation tools as they are introduced into workflows, and actively contribute ideas…