Co-op, Bioassay & Throughput Screening

This application is for a 6-month student role from January - June 2027. Resume review begins in October 2026. The Bioassay & High Throughput Screening (HTS) Co-op will join a multidisciplinary team focused on enabling early drug discovery through the development, optimization, and execution of robust biological assays. The Bioassay & HTS group partners closely with biology, and chemistry teams to identify and characterize novel therapeutic candidates using innovative screening technologies and automated laboratory platforms.

We execute high-throughput screening campaigns against large compound collections (+600K), confirm and characterize screening hits through follow up studies, generate concentration-response curves and potency measurements, and assess compound selectivity, assay interference, and toxicity. The Bioassay & HTS team delivers the assays, screening data, technologies, and scientific insights that enable researchers to discover and advance potential drug candidates. This work transforms biological questions into data-driven decisions that move drug discovery programs forward.

In this role, you will gain hands‑on experience supporting cell-based and biochemical assay workflows, operate advanced laboratory instrumentation, and contribute to high-throughput screening activities. You will work alongside scientists to generate high-quality data, troubleshoot experimental challenges, and help improve assay performance and operational efficiency. This position provides an opportunity to develop your technical laboratory skills, gain exposure to state-of-the-art screening and automation technologies, and contribute to research efforts aimed at advancing new therapies for patients.

• Execution of cell-based and biochemical assays to support research programs
• Preparation of reagents, assay plates and biological samples for screening experiments
• Collection, analysis, and interpretation of experimental data using data analysis tools
• Documentation of experimental procedures, results and conclusions in electronic laboratory notebook
• Contribution to assay optimization, automation workflows, and process improvement initiatives

• Optimization of assay technology by evaluating parameters such as cell density, incubation time, signal reagents and assay volume
• Compare different assay testing formats (384- vs. 1536 well) to improve throughput and reduce reagent consumption
• Prepare compounds in assay plates for testing

Include the knowledge, skills, and abilities you may be seeking.

• Fundamental understanding of biology, biochemistry, molecular biology or related scientific disciplines
• Knowledge of basic laboratory techniques, including solution preparation, pipetting, and experimental documentation
• Knowledge of serial dilutions and molarity conversions
• Ability to accurately execute experimental protocols and follow standard operating procedures
• Strong attention to detail and commitment to consistently generate high-quality, reproducible data
• Strong organizational and time management skills
• Effective written and verbal communication skills
• Prior laboratory research experience through coursework, academic research, or internships
• Interest in drug discovery, assay development, high-throughput screening, or laboratory automation
• Familiarity with cell culture and biochemical assays is a plus
• Experience with Graphpad Prism, Spotfire, Python, R or laboratory automation is a plus but not required