Scientist -Synthetic Organic Chemistry

Role Summary

Location:

Cambridge, MA. We are seeking a hands-on, bench-level Organic Chemist to join the Synthetic Enabling Technologies team within Process Chemistry. This Scientist role requires deep expertise in organic and process chemistry and strong skills in rapid reaction optimization to enable efficient scale-up from laboratory bench to manufacturing. You will develop and optimize synthetic routes for active pharmaceutical ingredients (APIs), collaborate with cross-functional teams to advance drug candidates from early development through clinical trials, and accelerate early clinical supply.

• Plan and conduct organic synthesis experiments and chemical reactions in the laboratory.
• Design, develop, and optimize synthetic routes for active pharmaceutical ingredients (APIs) using the right technology to allow smooth and rapid scale up to pilot-scale operations.
• Perform chemical analyses and compound characterization using a range of online/offline analytical techniques.
• Support technology transfer to manufacturing sites, fostering innovation and continuous improvement in synthetic methodologies.
• Troubleshoot technical issues at the interface of chemistry and manufacturing, providing effective solutions.
• Serve as the primary technical contact within the team, anticipating challenges and implementing proactive measures.
• Oversee and ensure the proper maintenance and operational readiness of specific scientific equipment.
• Communicate complex technical information clearly and effectively to multidisciplinary audiences and stakeholders.
• Mentor junior scientists and offer technical leadership and guidance.
• Document all experimental work and continuous improvement efforts in a digital lab notebook and compile findings into comprehensive technical reports.

• Required:
  
  Minimum 1 year of experience in synthetic organic chemistry and process development.
• Required:
  
  Demonstrated ability to translate laboratory processes to pilot/industrial scale.
• Required:
  
  Experienced in working on different types of chemical modalities i.e. small molecules, peptides, lipids.
• Preferred:
  Rapid extrapolation of chemical processes in early-phase process development for small molecules (pharma or biotech preferred).
• Preferred:
  Experience with automation platforms and digital tools for reaction monitoring and control.

• Organic Chemistry & Synthesis: designing and executing synthetic routes, understanding reaction mechanisms, troubleshooting chemical processes.
• Analytical
  
  Skills:
  
  chemical analysis techniques, chromatography (HPLC, GC), spectroscopy (NMR, MS, IR), data interpretation.
• Strong data management and analysis skills.
• Technical Problem-Solving: process troubleshooting, root cause analysis, risk assessment, solution development.
• Experience with digital lab notebooks, chemo informatics, or reaction databases.
• Languages:
  
  English fluent;
  French preferred.

• MSc in Organic Chemistry, Process Chemistry, or related field, with a strong academic record and proven expertise in synthetic organic chemistry.