Scientist II, Analytical Development

About This Role

At Biogen, we are seeking a Scientist

II to join our Analytical Development team as a Liquid Chromatography (LC) Subject Matter Expert (SME) and Analytical Project Lead. This role is pivotal, leveraging deep technical expertise in LC method development alongside leadership in analytical strategy across synthetics programs. Situated in Cambridge, MA, this lab‑based position plays a crucial part in driving forward the development of synthetic drug substances and products, ensuring robust, stability‑indicating methods.

• Serve as the LC subject matter expert, leading method development, optimization, qualification, and troubleshooting (HPLC, UHPLC, LC‑MS).
• Develop robust, stability‑indicating methods for synthetic drug substances and products.
• Provide technical support to inform analytical strategy for development programs from early to late stage.
• Collaborate cross‑functionally with CMC, formulation, process development, and quality teams.
• Provide oversight of analytical activities at CDMOs, including method validation, transfer, and lifecycle management aligned with regulatory expectations.
• Participate in mentoring and knowledge‑sharing activities to support analytical capability building within the organization.
• Contribute to programs involving emerging modalities (e.g., oligonucleotides and peptides).

You are enthusiastic about tackling complex analytical challenges to advance the development of small molecule therapeutics and oligonucleotides. You are motivated to learn new techniques and become a subject matter expert. You thrive both independently and collaboratively within a team setting, bringing a passion for scientific innovation and a commitment to excellence.

• Ph.D. with 0‑3 years of relevant experience in pharmaceutical or biotech settings
• M.S. with 4+ years of relevant experience in pharmaceutical or biotech settings
• BS with 6+ years of relevant experience in pharmaceutical or biotech settings
• Deep expertise in small molecule LC method development, with strong experience in HPLC/UHPLC and familiarity with LC‑MS
• Proven ability to lead analytical activities for drug development programs
• Strong knowledge of ICH guidelines and experience working within regulated (GMP/GLP) environments
• Excellent problem‑solving, communication, and cross‑functional collaboration skills

• Experience with oligonucleotides and/or peptides
• Advanced MS techniques (e.g., LC‑MS/MS, HRMS)

Management

Base compensation range: $–$. The salary is determined by a combination of factors including relevant skills & experience, job location, and internal equity. Regular employees are eligible to receive short‑term and long‑term incentives, including cash bonus and equity incentive opportunities.

• Medical, Dental, Vision, & Life insurances
• Fitness & Wellness programs including a fitness reimbursement
• Short‑ and Long‑Term Disability insurance
• Minimum of 15 days of paid vacation and additional end‑of‑year shutdown time off (Dec
  26–Dec
  31)
• Up to 12 company paid holidays + 3 paid days off for Personal Significance
• 80 hours of sick time per calendar year
• Paid Maternity and Parental Leave benefit
• 401(k) program participation with company matched contributions
• Employee stock purchase plan
• Tuition reimbursement up to $10,000 per calendar year
• Employee Resource Groups participation

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E‑Verify Employer in the United States.