Senior Principal Scientist, Discovery-Immunology

Job Description

Johnson & Johnson is searching for a Senior Principal Scientist, Discovery Immunology to join our team in Cambridge, MA. The role requires an experienced immunologist with a strong record of leading cross‑functional discovery programs and building high‑performing teams.

• Lead discovery‑stage research programs, driving strategy and execution across immunology therapeutic areas.
• Translate emerging biology into adaptable discovery strategies and develop innovative hypotheses for target validation and therapeutic concept development.
• Integrate in silico, in vitro, and in vivo data to inform decisions and advance assets, adapting approaches as new data emerge.
• Navigate shifting scientific priorities with high agility, rapidly evolving strategies and experimental direction.
• Contribute to portfolio strategy and represent programs in governance discussions.
• Operate effectively in a highly matrixed environment, partnering across functions to drive alignment and execution while influencing decisions through scientific expertise and clear communication.
• Mentor and develop scientists while fostering a collaborative, accountable, and high‑performing team environment.
• Lead by example and without formal authority to promote scientific rigor, effective ways of working, and drive team outcomes.

• Ph.D. in Immunology, Biology, or a related discipline with 5–7 years of extensive drug discovery experience.
• Demonstrated track record of advancing programs, leading cross‑functional teams, and applying immunology expertise to inform discovery strategy.
• Proven ability to operate effectively in dynamic, matrixed environments.
• Strong written and verbal communication and stakeholder influence skills to drive both scientific outcomes and team development.
• Experience conducting due diligence and evaluation of business development opportunities (preferred).
• Up to 10% travel required.

Employees and eligible dependents may participate in the following company‑sponsored benefit programs: medical, dental, vision, life insurance, short‑ and long‑term disability, business accident insurance, group legal insurance, and a consolidated retirement plan (pension and 401(k)).

• Vacation –120 hours per calendar year
• Sick time – 40 hours per calendar year (56 hours in Washington State)
• Holiday pay, including floating holidays – 13 days per calendar year
• Work, Personal and Family Time – up to 40 hours per calendar year
• Parental Leave – 480 hours within one year of birth/adoption/foster care of a child
• Condolence Leave – 30 days for an immediate family member, 5 days for an extended family member
• Caregiver Leave – 10 days
• Volunteer Leave – 4 days
• Military Spouse Time‑Off – 80 hours

The anticipated base pay range for this position is $137,000 – $235,750.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status, or any other characteristic protected by federal, state, or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.