Senior Associate Scientist, In Vivo Pharmacology, Oncology Discovery Biology

R1603459 :
Senior Associate Scientist, In Vivo Pharmacology, Oncology Discovery Biology

This role is located in Cambridge, MA and supports the Oncology Discovery Pharmacology and In Vivo Biology group at Bristol‑Myers Squibb. The senior associate scientist will advance early‑stage therapeutics in Oncology TRC, working on immuno‑oncology programs such as T‑cell engager platforms and directly impacting preclinical drug development from target identification through IND enabling activities.

The successful candidate will conduct in‑vivo pharmacology experiments, including model development, tumor implantation, dosing via IV, IP, SC, IT, IM, and PO routes, tumor measurements, health monitoring, tissue sampling, and ex vivo analyses. The role requires strong collaboration with Discovery Oncology, protein engineering, DMPK, and translational groups, and the ability to present findings to multidisciplinary teams.

• Design and execute mouse in‑vivo pharmacology protocols: model development, tumor implantation, dosing via IV, IP, SC, IT, IM, PO, tumor measurements, health monitoring, tail‑vessel micro‑sampling, cardiac puncture, necropsy tissue collection, fixation, freezing, and disaggregation for ex vivo assays.
• Collaborate with the team to conduct in‑vivo efficacy and PK/PD studies and support new pharmacology model development.
• Execute end‑to‑end flow cytometry workflows: panel design and establishment, multiparametric profiling of blood, tumor, and lymphoid tissues, downstream data analysis, and communication of results to cross‑functional teams.
• Isolate PBMC and primary T cells from leukopaks and perform functional characterization using cell‑based assays.
• Maintain accurate scientific documentation in an electronic lab notebook.
• Effectively communicate and present research summaries to team members and multidisciplinary research groups.

• Bachelor’s Degree with 4+ years of academic and/or industry experience, or Master’s Degree with 2+ years of academic and/or industry experience.

• B.S. with 2–7 years of relevant industry or comparable academic experience and demonstrated in‑vivo and ex‑vivo oncology skill sets.
• Experience with subcutaneous syngeneic and xenograft tumor models; preferred experience with orthotopic, chemically induced mouse models, GEMMs, and PDx models.
• Competency in murine dosing IV, IP, SC & PO; intra‑tumor and IM preferred. Rodent surgical experience is a plus.
• Proficiency in cell culture, passaging, harvesting, and preparation of adherent and suspension mammalian cells for subcutaneous and intravenous implantation.
• Experience independently processing blood samples, harvesting and disaggregating tumors, spleen, and lymph nodes for FACS analysis.
• Experience setting up basic FACS multichannel panels (5–6 color) and routine profiling of tumors, blood, and lymphoid organs by flow cytometry, including data analysis and presentation.
• Familiar with cytokine profiling studies using MSD & Luminex methods.
• Proficiency with Graph Pad Prism, electronic notebooks, Microsoft Office, and data analysis/figure generation.
• Excellent organizational skills and a detail‑oriented approach to experiment execution and record‑keeping.
• Strong interpersonal skills and ability to interact effectively with peers and management.

Cambridge Crossing: $105,040 – $127,287 (full‑time employee). Additional incentive cash and stock opportunities may be available based on eligibility.

• Health Coverage:
  Medical, pharmacy, dental, and vision care.
• Well‑being Support: BMS Well‑Being Account, BMS Living Life Better, Employee Assistance Programs (EAP).
• Financial Protection: 401(k) plan, disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work‑life Benefits:
  Flexible time off, unlimited paid sick time, up to 2 paid volunteer days per year, summer hour flexibility, leave options for medical, personal, parental, caregiver, bereavement, and military needs, and an annual Global Shutdown.

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