Senior Manager, Clinical Operations - Cardiology

Senior Manager, Clinical Operations – Cardiology

Location:

Cambridge, Massachusetts and New York, New York. Hybrid work: in‑office collaboration two days per week in either New York City or Boston office.

Study Activation Ownership & Execution

• Own the end‑to‑end site activations, managing timelines, dependencies, and risks across multiple concurrent sites and trials
• Help teams prioritize tasks and ensure milestones are met within defined SLAs
• Maintain activation plans, status tracking, and documentation, escalating risks and delays proactively

Sponsor & CRO Partnership

• Serve as the primary operational partner to sponsors, CROs, and sites throughout the trial lifecycle
• Lead and support sponsor, CRO, and partner meetings by providing clinical operations expertise, actionable insights, and strategic recommendations
• Build strong relationships with key stakeholders and ensure alignment on study goals, performance metrics, and operational priorities
• Proactively communicate study risks, mitigation plans, and escalation strategies
• Facilitate educational sessions, webinars, and customer forums to strengthen engagement and share best practices
• Travel as needed to customer sites, investigator meetings, conferences, and sponsor engagements (up to 30%)

Study Performance & Operational Excellence

• Monitor study performance metrics and own activation‑specific reporting, including time‑to‑activation, SLA performance, and root causes of delays
• Build and maintain dashboards that provide clear stakeholder visibility
• Use data to inform prioritization, process improvements, and resourcing decisions
• Identify operational gaps affecting site activation, enrollment, and execution, and collaborate cross‑functionally to address them
• Advocate for site needs and serve as a subject matter expert in clinical research operations
• Collaborate cross‑functionally to implement solutions that improve site performance and study outcomes
• Partner with sponsors and CROs to streamline processes and optimize site activation timelines
• Perform related duties as requested

• Bachelor’s degree or equivalent combination of education and experience
• 8+ years of experience supporting Phase II–IV sponsor‑funded clinical trials
• Deep understanding of clinical trial operations, including study startup, feasibility, regulatory processes, protocol execution, and GCP requirements
• Experience working directly with sponsors, CROs, investigative sites, and cross‑functional stakeholders
• Demonstrated ability to manage multiple priorities, navigate ambiguity, and drive projects to successful completion
• Strong analytical, communication, and stakeholder management skills
• Comfort adopting and leveraging new technologies and operational tools
• Willingness to travel up to 30%

• Experience in cardiology clinical research
• Prior project or program management experience
• 5+ years of experience as a Clinical Research Associate (CRA) or Clinical Research Coordinator (CRC), or 3+ years leading clinical operations teams
• Experience with CTMS platforms, with Real Time CTMS strongly preferred
• Experience working in a high‑growth or startup environment
• Experience presenting to sponsors, CRO leadership, and executive stakeholders

• Hybrid work environment with in‑office collaboration two days per week in either our NYC or Boston office
• Comprehensive medical, dental, and vision coverage, with up to 80% of premiums covered by Iterative Health
• Mental health and wellness support through Spring Health
• Health HSA or FSA options, and commuter FSA contributions supported by Iterative Health
• Unlimited PTO, 12 company holidays, and a company‑wide shutdown between Christmas and New Years
• 401(k) program with a company match of up to 3% (up to $3,000 annually)
• Weekly in‑office lunch benefit every Tuesday
• 100% company‑paid short‑term and long‑term disability coverage
• Annual wellness and professional development stipend to support your health and growth
• And more!

As set forth in Iterative Health’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.