Associate Scientist, Synthesis Process Development

Position Summary

Bristol Myers Squibb is seeking a motivated and detail-oriented Associate Scientist to join our RNA Synthesis Process Development team in Cambridge, MA. The RNA PD team develops, characterizes, and implements robust preclinical and clinical manufacturing processes to support Bristol Myers Squibb’s exciting pipeline of products. This role focuses on RNA synthesis process development, including early process development through clinical manufacturing support.

• Execute hands‑on laboratory experiments focused on RNA synthesis process development and scale‑up from bench to pilot scale
• Design and perform experiments for optimization and characterization of in vitro transcription reactions using structured approaches (e.g., QbD principles, DoE)
• Support routine downstream purification unit operations (e.g., chromatography, UF/DF) and contribute to process optimization efforts that bridge synthesis and purification workflows
• Contribute to the authoring and review of technical protocols, experimental reports, and batch records in support of early‑to‑late‑stage development activities
• Perform routine analytical testing to assess RNA purity, concentration and key quality attributes
• Analyze and interpret experimental results, present findings to senior scientists and project teams
• Collaborate with internal R&D, analytical development, and manufacturing to advance BMS’s RNA pipeline
• Support interactions with manufacturing partners, including review of technical documents and participation in technology transfer activities as needed
• Maintain accurate and complete laboratory notebooks and documentation in compliance with internal quality standards

• BS with 1+ years of industry experience, or MS with relevant experience, in Chemical Engineering, Biomedical Engineering, Biochemistry, or a related scientific discipline
• Hands‑on experience with RNA synthesis techniques, specifically in vitro transcription
• Familiarity with analytical tools used to assess RNA quality, including gel electrophoresis, HPLC, or capillary electrophoresis
• Basic understanding of RNA purification unit operations
• Strong laboratory fundamentals and attention to detail; comfortable working with bench‑top equipment including bioreactors, FPLCs, and UF/DF skids
• Ability to organize and analyze experimental data, identify trends, and clearly communicate results to team members
• Exposure to GMP principles or cGMP environments is a plus but not required
• Experience with design of experiments (DoE) or statistical analysis software is a plus

Cambridge - MA: US $96,010 – $116,339 (full‑time, FTE). Additional incentive cash and stock opportunities may be available. Final, individual compensation will be decided based on demonstrated experience.

• Health Coverage:
  Medical, pharmacy, dental, and vision care
• Well‑being Support Programs: BMS Well‑Being Account, BMS Living Life Better, Employee Assistance Programs (EAP)
• Financial Well‑being and Protection: 401(k) plan, short‑ and long‑term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support

Paid Time Off and additional benefits vary by location and employment status. Employees may receive unlimited paid time off (with manager approval) and 11 paid national holidays. Additional policies include paid sick time, volunteer days, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs, and a global shutdown.

The occupancy structure determines where an employee is required to conduct their work. Site‑essential roles require 100% of shifts onsite at the assigned facility. Site‑by‑design roles may be eligible for a hybrid work model with at least 50% onsite. Field‑based and remote‑by‑design roles may require travel to visit customers, patients, or business partners as an essential job function.

BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in the area.

Applicants can request reasonable workplace accommodations or adjustments prior to accepting a job offer. For assistance, contact  For full Equal Employment Opportunity statement, visit

We will never request payments, financial information, or social security numbers during our application or recruitment process.

R1603729 – Associate Scientist, Synthesis Process Development