Associate Scientist, Synthesis Process Development

Position Summary:

Bristol Myers Squibb is seeking a motivated and detail‑oriented Associate Scientist to join our RNA Synthesis Process Development team in Cambridge, MA. The role focuses on RNA synthesis process development, spanning early process development to clinical manufacturing support.

• Execute hands‑on laboratory experiments focused on RNA synthesis process development and scale‑up from bench to pilot scale.
• Design and perform experiments for optimization and characterization of in vitro transcription reactions using structured approaches (e.g., QbD principles, DoE).
• Support routine downstream purification unit operations (e.g., chromatography, UF/DF) and contribute to process optimization efforts that bridge synthesis and purification workflows.
• Contribute to the authoring and review of technical protocols, experimental reports, and batch records in support of early‑to‑late‑stage development activities.
• Perform routine analytical testing to assess RNA purity, concentration, and key quality attributes.
• Analyze and interpret experimental results, present findings to senior scientists and project teams.
• Collaborate with internal R&D, analytical development, and manufacturing to advance BMS’s RNA pipeline.
• Support interactions with manufacturing partners, including review of technical documents and participation in technology transfer activities as needed.
• Maintain accurate and complete laboratory notebooks and documentation in compliance with internal quality standards.

• BS with 1+ years of industry experience, or MS with relevant experience, in Chemical Engineering, Biomedical Engineering, Biochemistry, or a related scientific discipline.
• Hands‑on experience with RNA synthesis techniques, specifically in vitro transcription.
• Familiarity with analytical tools used to assess RNA quality, including gel electrophoresis, HPLC, or capillary electrophoresis.
• Basic understanding of RNA purification unit operations.
• Strong laboratory fundamentals and attention to detail; comfortable working with bench‑top equipment including bioreactors, FPLCs, and UF/DF skids.
• Ability to organize and analyze experimental data, identify trends, and clearly communicate results to team members.
• Exposure to GMP principles or cGMP environments is a plus but not required.
• Experience with design of experiments (DoE) or statistical analysis software is a plus.

Salary range: $96,010 – $116,339 per year. Additional incentive cash and stock opportunities (based on eligibility) may be available. Final individual compensation will be decided based on demonstrated experience.

• Health coverage: medical, pharmacy, dental, and vision care.
• Well‑being support: BMS Well‑Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial well‑being and protection: 401(k) plan, short‑ and long‑term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity‑theft benefit, legal support, and survivor support.
• Work‑life benefits: paid time off, flexible time off (unlimited with manager approval), paid national holidays, paid volunteer days, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs, and an annual Global Shutdown.

Bristol Myers Squibb is an equal‑opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. The company complies with all applicable federal, state, and local laws regarding equal employment opportunity.