Senior Scientist, Cell Therapy Islet

What you’ll do:

• Execute routine 2D and 3D PSC expansion, passaging, and directed SC-islet differentiation
• Design optimization experiments to achieve a scalable, robust 3D SC-islet differentiation process compliant with manufacturing standards
• Optimize differentiation protocol for highly pure on-target populations
• Operate closed systems (tube welder, sealer, single-use assemblies)
• Set up and run controlled bioreactors; manage automation and process control (DO, pH, perfusion, agitation)
• Collaborate and communicate experimental findings
• Maintain strong scientific documentation; contribute to SOP development
• Ensure lab safety and biosafety compliance
• Contribute to team execution and feedback; support multidisciplinary collaboration while meeting deadlines

• PhD in stem cell biology or biochemical/biomedical engineering (or related) with 3–5 years of direct cell therapy industry experience
• Strong experience operating suspension culture bioreactors
• Bioreactor control software/process development tools and/or DOE-based optimization (preferred)
• Experience operating closed cell culture systems
• Flow cytometry and immunofluorescent staining experience
• Proficiency with flow cytometry/imaging software (e.g., FACSDiva, Flow Jo, ImageJ, Halo)

• Directed stem cell differentiation toward pancreatic islet lineage
• Ability to optimize differentiation yield and reproducibility across platforms
• Interest in GMP transition, automation, and continuous process improvement
• Experience with large bioreactors (15L+)
• Cross-functional collaboration experience advancing cell therapies to the clinic

Base pay range: $160,000–$190,000/year (varies by factors such as location, knowledge, skills, and experience)