Human Genetics Laboratory Leader

Key Responsibilities

• Lead and develop a team of 2-3 wet lab scientists; establish experimental capabilities to functionally characterize human genetic variation.
• Manage resources, priorities, and execution across multiple projects to ensure high-quality data generation, interpretation, and delivery.
• Enable recall-by-genotype strategies, including participant identification from biobank resources and design of deep phenotyping protocols.
• Evolve the genotype-to-phenotype strategy by translating rare variants into biological hypotheses and target investment decisions.
• Represent genetics expertise in cross-functional teams and governance boards for portfolio prioritization.
• Build and maintain internal/external partnerships and communicate scientific insights to diverse audiences.

• PhD with 8+ years post‑graduate experience in genetics, focused on rare variants and/or genotype‑to‑phenotype translation.
• Strong experimental biology background (cellular models; gene perturbation technologies for variant characterization).
• Extensive experience linking clinical/biobank genetic data to biological mechanisms and therapeutic hypotheses across disease areas.
• Proven people leadership/mentoring skills; ability to influence in a matrix environment.
• Interest in emerging methods, including AI‑based variant interpretation/prioritization.
• Exceptional collaboration, communication, and problem‑solving; strong track record of scientific innovation.

• Hands‑on experience designing/executing recall-by-genotype studies.
• Target and/or drug discovery industry experience.

$138,600–$257,400 (Senior Principal Scientist) or $152,600–$283,400 (Associate Director) annually, plus performance‑based cash incentive; annual equity may be available.

Cambridge, MA (onsite). Relocation support not provided.