Senior Director, HEOR & Evidence Strategy

Senior Director, HEOR & Evidence Strategy

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

Beyond our science, we live our four core values:
One, Explore, Disrupt, Deliver and feel strongly that you can achieve more  have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.

We want all of our people to go beyond what is possible. We aren't constrained by typical end rails, and we aren't out to just "treat" people. We're all in this for something more. We're driven to cure and motivated for change. Just imagine the possibilities of what we can do together.

How You Will Achieve More:

Intellia Therapeutics, a pioneer in gene editing, is preparing for its first launch of one-time gene editing therapies for rare and serious diseases, including hereditary angioedema (HAE) and transthyretin amyloidosis (ATTR). The Senior Director, HEOR & Evidence Strategy will be responsible for setting and executing the integrated evidence strategy to demonstrate value and enable durable access, while also leading Field HEOR to drive payer engagement and inform U.S. coverage and reimbursement decisions.

This role is the linchpin between global evidence generation and U.S. payer-facing execution—overseeing the Director, HEOR & Evidence Strategy and managing the Field HEOR team. The Senior Director will translate science and economics into compelling value narratives, ensure evidence is embedded into clinical development, and directly support national and large regional payer strategies with robust, credible data.

This is a highly strategic, hands-on role that is ideal for an experienced HEOR professional who thrives in fast-paced, build-from-scratch environments and understands the complexity of launching innovative, high-value therapies.

• Own the Integrated Evidence Generation Plan (IEGP) across programs; align with clinical development, medical affairs, and commercial strategy.
• Design and implement global HEOR strategies to support pricing, reimbursement, and launch readiness across major markets (U.S. and ex-U.S.).
• Lead development of evidence frameworks for one-time gene editing therapies (lifetime value, durability, long-term uncertainty).
• Oversee primary/secondary research (e.g., HTA scans, systematic literature reviews, retrospective analyses, burden of illness, time & motion studies).

• Direct development of cost-effectiveness models, budget impact models (BIM), and scenario analyses for payer decision-making.
• Lead creation and continuous refinement of value narratives, global value dossiers (GVD), AMCP Dossier, and payer decks.
• Coordinate HTA submissions and engagement (e.g., NICE, ICER), ensuring methodological rigor and alignment with local value frameworks.
• Ensure evidence and economic modeling are integrated into pricing strategy, access models, and value-based agreement designs.

• Oversee RWE strategy to demonstrate durability, effectiveness, and safety post-launch; develop PROs and quality-of-life instruments fit for rare disease.
• Guide claims/data collaborations and outcomes research to inform unmet need, treatment pathways, and value demonstration across stakeholders.
• Lead scientific communications (abstracts, posters, manuscripts) and congress representation.

• Build and lead the Field HEOR team; serve as the senior scientific leader for payer-facing HEOR engagements across commercial, Medicare, and Medicaid segments.
• Partner with National Account Directors on account planning, segmentation, and tailored evidence deployment to optimize payer engagement.
• Present clinical, economic, and RWE data to Medical and Pharmacy Directors; address medical policy development and utilization management strategies.
• Train and mentor field teams and National Account Directors on HEOR concepts, evidence interpretation, and value messaging;…