Head of Discovery & Translation

We think differently, act boldly, and push boundaries in pursuit of new heights.

We’re building a team of scientists and drug developers committed to translating the field of up regulation into transformative medicines.

The journey is exhilarating. The view from the top is breathtaking. Join us at the forefront.

Pioneering a new approach to up regulate genes

To change the lives of countless patients with diseases caused by inadequate gene expression

CAMP4 values the strength that diversity brings to the workplace. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, religion, color, sex, gender identity, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status or any other characteristic protected by applicable law.

Head of Discovery & Translation

Reports To: Chief Scientific Officer

Location: Cambridge, MA

CAMP4 is seeking a dynamic and experienced Head of Discovery & Translation, reporting to our Chief Scientific Officer (CSO), to lead a team of Discovery, Oligonucleotide, and Preclinical scientists driving our CNS-focused pipeline. This role will span target inception through IND-enabling studies and will play a critical role in shaping the pipeline. CAMP4 is focused on discovery of novel regRNA-targeting therapies to up regulate gene expression for CNS disorders.

This leader will combine deep scientific expertise in nucleic acid therapeutics with strong operational and organizational leadership, driving high-quality, decision-enabling science while fostering a collaborative, entrepreneurial culture.

• Provide strategic and scientific leadership across a growing pipeline from target identification through discovery program execution, IND/CTA-enabling studies, and regulatory submissions.
• Oversee Discovery, Preclinical, and Oligonucleotide Chemistry functions, integrating and aligning teams to drive pipeline programs and support pharma partnerships.
• Drive target prioritization, resource allocation, and technical oversight across discovery programs to ensure generation of high-quality, decision-enabling data and effectively transition programs from research to development.
• Partner with Platform leadership and scientific team to ensure cross-functional alignment, in order to efficiently drive pipeline programs to key go/no-go decision points and program criteria.
• Drive translational strategy to support program transition to clinical development, including disease biomarkers discovery, along with supporting human dose selection strategy with translational pharmacology and nonclinical safety data.

• Serve as a thought partner to the CSO on pipeline strategy, portfolio prioritization, and external landscape.
• Partner closely with Platform leadership to align scientific strategy, operational execution, and resource prioritization.
• Collaborate with cross-functional partners including CMC, Regulatory, Clinical, Finance, Legal, and Business Development to align discovery efforts with broader company objectives.

• Lead a team of Directors and Managers, as well as Discovery and Translational scientists. Provide mentorship and development focused on developing team for organizational growth as the pipeline matures.
• Foster a scientifically rigorous, collaborative, and entrepreneurial culture that is mission-focused to advance novel therapies to patients.

• PhD in molecular biology, pharmacology, biochemistry, or related field.
• Significant industry experience in drug discovery and development, with demonstrated leadership of multidisciplinary teams and senior scientists.
• Proven track record advancing nucleic acid-based therapeutics from discovery into development, including either antisense oligonucleotides or siRNA.
• Experience with preclinical safety, including direct responsibility or management of external consultants.
• Experience with oligonucleotide-based drug discovery for CNS disorders is preferred.
• Experience with regulatory documentation, strategy, and interactions and filings.
• Experience in translational research and early clinical development, including biomarkers and pharmacology.
• Ability to integrate platform science with pipeline development decisions.
• Experienced leader of sizable…