Associate Researcher

Overview

Location: Canton MA

About the Company: Pledge Therapeutics is an innovative start-up dedicated to advancing treatments in immunology and virology. We are passionate about developing novel therapies addressing unmet medical needs in immune-oncology and viral infections. Leveraging our state-of-the-art discovery platform, we have developed high-quality medicinal leads for multiple exciting drug targets that can potentially revise existing treatment paradigms.

About the Role: We are seeking a highly motivated Research Associate to support protein production and structural biology operations at our Canton site. This is a hands-on role central to our structure-enabled discovery engine. You will contribute directly to rapid experimental turnaround by enabling high-quality protein supply, supporting crystallization workflows, and maintaining robust experiment tracking and data integrity. This role is ideal for an RA who thrives in a fast-paced environment, enjoys building reliable workflows, and wants to grow deeper into Structural Biology.

• Protein Production
  :
  Execute routine protein expression, purification, QC, and documentation (e.g., PCR, ÄKTA/FPLC chromatography, SDS-PAGE) to support structural studies.
• Crystallization & Structural Biology Operations
  :
  Perform high-throughput crystallization setup and follow-up (plate setup, monitoring/scoring, optimization, crystal handling) following stablished protocols and optimizations plans
• Data, Tracking & Process Ownership
  :
  Maintains accurate sample/experiment tracking and database updates, including protein lot traceability, crystallization condition logs, crystal inventory, and maintains detailed electronic lab notebooks.
• Collaboration & Communication
  :
  Works cross-functionally with structural biologists and medicinal chemists to communicate progress and timelines, raise questions or issues for discussion with senior team members in a fast-paced discovery environment.

• BS or MS in Biochemistry, Molecular Biology, Biophysics, or a related field, with 0–2 years of relevant laboratory experience.
• Demonstrated hands-on experience with molecular cloning,
  protein purification and chromatography workflows (PCR/ÄKTA/FPLC strongly preferred).
• Strong experimental rigor, organization, and attention to detail, follow established protocols, identify basic issues, and seek guidance when needed.
• Thrive in a fast-moving environment and work collaboratively across teams.
• Authorization to work in the U.S.

• Experience with protein crystallization and/or structural biology workflows.
• Strong analytical, organizational, communication and time management skills

Equal Opportunity Employment. Employment Authorization Required

If you are interested in contributing your expertise in protein biochemistry, biophysics, and structural biology to advance novel therapies in immuno-oncology and virology, please send your resume and a brief note to our hiring team.