Post Doctorate Fellow, Receptors Enable Targeted Oligonucleotide Delivery

Post Doctorate Fellow, Discovering Receptors That Enable Targeted Oligonucleotide Delivery to Immune Cells

Ionis is an RNA therapeutics company headquartered in Carlsbad, CA, with additional offices in Boston, MA, and Dublin, Ireland.

We are seeking a highly motivated Post Doctorate Fellow to advance targeted RNA‑therapeutics delivery to immune cells. This role offers a unique opportunity for deep research experience in a fast‑paced industry environment while contributing to next‑generation RNA medicines.

• Identify and prioritize cell‑surface receptors relevant to immune‑cell biology, applying scientific creativity and critical thinking.
• Validate receptor expression and function using flow cytometry, single‑cell profiling, and RNA‑seq.
• Design and execute in vitro and in vivo studies to evaluate target knockdown, delivery efficiency, and cell‑type specificity.
• Analyze and interpret complex datasets to guide decision‑making and shape project strategy.
• Document experimental results and communicate findings through internal presentations, manuscripts, and posters.
• Collaborate effectively with cross‑functional teams and external partners to align on technical decisions.
• Contribute to innovation and intellectual property development through rigorous experimentation and documentation.
• Demonstrate professionalism and uphold the company’s culture, core principles, and collaborative norms.

• Ph.D. in Immunology, Molecular Biology, Cell Biology, or related fields with 0‑3 years of postgraduate training.
• Familiarity with flow cytometry, including panel design and data analysis.
• Experience with cell culture techniques, including primary immune cell isolation and maintenance.
• In vivo study experience or willingness to learn.
• Experience with molecular biology methods (e.g., RNA analysis, qPCR, siRNA/ASO delivery).
• Strong background in immunology and lymphocyte biology preferred.
• Ability to analyze large datasets (e.g., scRNA‑seq, transcriptomics) and interpret receptor expression profiles.
• Excellent problem‑solving skills and ability to design experiments independently.
• Strong written and verbal communication skills for publication and presentation.
• Required to be full‑time onsite at Carlsbad, CA.

Pay range: $65,000 to $87,000.

Ionis offers a comprehensive benefits package.

Equal Opportunity Employer. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers. This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.