Scientist III, Bioinformatics

Work Schedule

Standard (Mon-Fri)

Office

Support primer design and the development of targeted sequencing panels, building pipelines and algorithms for next-generation sequencing within our Bioinformatics R&D team in the Clinical Next Generation Sequencing Division.

This is a fully onsite role based in Carlsbad, CA or South San Francisco, CA.

• Design assays for custom targeted sequencing panels for external and internal researchers
• Understand key scientific questions and translate them into effective assay design strategies
• Partner with external customers to understand project requirements and deliver high-quality design solutions that meet their needs
• Collaborate cross-functionally with molecular biologists, product management, and other bioinformatics and software team members to support new product development, launch, troubleshooting, and optimization
• Develop, maintain, and operate bioinformatics pipelines for assay design, data mining and analysis
• Improve assay designs through iterative analysis of sequencing data and development of heuristics, optimization methods, and algorithms
• Evaluate, implement, and scale new technologies and methods to optimize and automate pipelines for primer design

• PhD in bioinformatics, statistics, genomics, computational biology, computer science or related field; or
• MS with 3+ years of relevant industry experience

• Proficiency in Python and shell scripting
• Hands‑on experience with bioinformatics production systems
• Experience with targeted NGS sequencing, Ampliseq technology or PCR primer design is highly preferred
• Experience with sequence analysis tools (BLAST, MAFFT/Clustal, Bowtie/BWA, samtools/bedtools) and strong understanding of genomic databases and annotations (Gen Bank/Ref Seq, ENSEMBL, UCSC)
• Working knowledge of statistical modeling, optimization, or machine learning applied to genomic or assay‑design data
• Experience applying modeling or machine learning approaches to support assay performance prediction, off‑target assessment, QC flagging, or design‑rule optimization is preferred

• Excellent communication and organizational skills
• Self‑motivated, collaborative, and detail‑oriented
• Strong problem‑solving and troubleshooting skills
• Commitment to delivering high‑quality results with integrity and professionalism

• Must be legally authorized to work in the United States without sponsorship now or in the future
• Must be able to pass a comprehensive background check and drug screen

The salary range estimated for this position based in California is $95,900.00–$.

• A choice of national medical and dental plans, and a national vision plan, including health incentive programs
• Employee assistance and family support programs, including commuter benefits and tuition reimbursement
• At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short‑and long‑term disability in accordance with company policy
• Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
• Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount

For more information on our benefits, please visit: