Scientist II, Protein Modification

Scientist II, Protein Purification

We are seeking a Scientist II, Protein Purification to join our growing team in Carlsbad, CA. This role is responsible for executing and supporting protein purification and manufacturing operations within a controlled laboratory environment. The ideal candidate will have hands-on experience with chromatography-based purification processes, tangential flow filtration (TFF), and protein characterization techniques while maintaining compliance with quality and documentation requirements.

This is an excellent opportunity for a scientist with a strong background in downstream processing who enjoys working in a collaborative, fast-paced manufacturing environment.

• Execute protein purification processes using Cytiva ÄKTA FPLC systems (UNICORN software) and/or Bio-Rad NGC chromatography systems.
• Perform chromatography operations including: affinity chromatography, ion exchange chromatography, size exclusion chromatography, and other protein purification methodologies.
• Conduct tangential flow filtration (TFF) processes for protein concentration, diafiltration, and purification.
• Prepare buffers, reagents, and process solutions according to standard operating procedures.
• Perform analytical testing and characterization, including SDS-PAGE and other protein quality assessments.
• Monitor process performance and evaluate chromatography data to ensure product quality and process efficiency.
• Troubleshoot technical and process-related issues and assist with deviation investigations.
• Maintain laboratory equipment and manage inventory of materials and supplies.
• Support process optimization initiatives, validation activities, and equipment qualifications.
• Collaborate closely with Manufacturing, Quality Assurance, Quality Control, and Technical Operations teams.
• Ensure compliance with quality systems, safety procedures, and controlled documentation practices.

• Bachelor's degree in Biology, Biochemistry, Chemistry, Biotechnology, or a related scientific discipline.
• Minimum 3 years of hands-on protein purification experience in a laboratory, manufacturing, or bioprocessing environment.
• Experience executing end-to-end protein purification processes, including buffer preparation, protein characterization, process monitoring, yield optimization, and troubleshooting.
• Hands-on experience operating Cytiva ÄKTA FPLC systems with UNICORN software and/or Bio-Rad NGC chromatography systems.
• Strong understanding of protein chemistry and downstream processing principles.
• Experience with tangential flow filtration (TFF).
• Familiarity with quality systems, GMP-regulated environments, or controlled documentation practices.
• Strong analytical, troubleshooting, and problem-solving skills.

• Experience supporting manufacturing-scale protein production.
• Previous involvement with process development, validation, or technology transfer activities.
• Experience working in regulated biotechnology, pharmaceutical, or life sciences environments.

• Ability to work onsite in a laboratory and manufacturing setting.
• Comfortable working in cold room environments (approximately 4°C / 39°F).
• Ability to stand for extended periods during the workday.
• Ability to lift and move laboratory materials and equipment as needed.
• Flexibility to support production schedules and business needs.

You'll have the opportunity to work alongside a collaborative team of scientists and industry professionals focused on developing and manufacturing high-quality protein products. This role offers hands-on involvement with advanced purification technologies and the chance to contribute directly to process improvements and operational excellence.

Apply today to join a team dedicated to scientific innovation and manufacturing excellence.

Job Type &

Location:

This is a Contract position based out of Carlsbad, CA.

Pay and Benefits:

The pay range for this position is $30.00 - $40.00/hr individual compensation offered for this position within this range will depend on many factors, including qualifications, skills, relevant experience, job knowledge, geographic…