Postdoctoral Fellow (NIEHS

NIH National Institutes of Environmental Health Sciences, Research Triangle Park, NC

Scientific focus area

Systems Biology,Computational Biology

The NIEHS Computational and Systems Biology Group, within the Biostatistics & Computational Biology Branch, is now seeking a postdoctoral fellow to join their team.

This fellowship will focus on developing causal AI and computational methods for analyzing single-cell perturbation and multi-omics data in order to investigate disease mechanisms and advance precision medicine.

Prospective candidates will develop and apply advanced computational, statistical, and AI/ML methods to analyze large-scale perturbation datasets generated using CRISPR-based functional genomics technologies, including Perturb-seq, CRISPRi, CRISPR knockout, pooled genetic screens, and pharmacological and/or environmental perturbation experiments.

Research will further focus on developing interpretable causal inference methods to reconstruct gene regulatory networks, signaling pathways, and cellular state transitions from single-cell perturbation data using probabilistic graphical models, mechanistic systems biology models, causal discovery algorithms, graph neural networks, and perturbation-based frameworks such as Nested Effects Models (NEMs).

These methods will be evaluated and applied using large-scale multimodal datasets that integrate genomic, transcriptomic, epigenomic, proteomic, metabolomic, single-cell, and spatial molecular profiling data together with public reference resources, including the Human Cell Atlas, and other national and international consortium datasets.

Current projects include characterizing spatial molecular responses following ischemic kidney injury and investigating how genetic variation and environmental exposures influence cellular responses, immune dynamics, and disease susceptibility across diverse biological systems.

U.S. citizens and permanent residents are eligible to apply. NIH welcomes foreign nationals with the exception of individuals from this list .