Scientist ; LC-MS​/MS

Job Description

Quantitative, Translational & ADME Sciences Department has an open position for a Scientist I in North Chicago, IL.

The successful candidate will be responsible for non-regulated quantitative LC-MS/MS bioanalysis of small molecules from in vivo and in vitro samples, including extraction, data analysis and interpretation.

First Shift, Mon-Fri, 8am – 5pm (possibility of earlier than 8am depending on job tasks).

Level and compensation will be commensurate with experience.

• Use liquid handling robotics.
• Perform quantitative LC-MS/MS (Liquid Chromatography Mass Spectrometry) analysis of small molecules from various bio-matrices in vivo and in vitro to support PK/PD, ADME, efficacy, and exploratory toxicology studies.
• Basic Operation and troubleshooting of AB Sciex LC-MS/MS systems.
• Maintain excellent documentation of all work including LIMS, test methods, and protocols.
• Work closely with multiple teams across Discovery and DMPK-BA to support bioanalysis.

• B.S. in analytical chemistry or related field years of relevant academic/pharmaceutical industry experience.
• Knowledge of protein precipitation, liquid/liquid extraction, and solid phase extraction.
• Ability to operate and troubleshoot HPLCs, Leap/CTC PAL autosamplers and triple quad mass spectrometers.
• Experience with quantitative bioanalysis of small molecules.
• Knowledge of chromatographic and analytical methodologies.
• The ideal candidate is detail oriented and committed to generating high-quality results within tight deadlines and across different projects.
• Proven ability to work independently or under minimal supervision in a high-throughput environment to design and conduct experiments, interpret, document, and communicate results, as well as in a team environment to collaborate successfully across other groups within R&D.
• Strong communication, interpersonal, and presentation skills.
• Experience operating and troubleshooting current LC-MS/MS platforms (Agilent HPLCs, Leap/CTC PAL and ADDA autosamplers, Sciex API-5500/6500 triple quad Mass Spectrometers) and software (Discovery Quant, Analyst, Electronic notebook) is highly preferred.

• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
• Learns fast, grasps the "essence" and can change course quickly where indicated. Raises the bar and is never satisfied with the status quo.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.