UNIV - Staff Scientist - Department of Biochemistry

Job Description Summary

Applications are invited for a full-time Staff Scientist position available in the O’Bryan lab in the Department of Biochemistry and Molecular Biology at the Medical University of South Carolina and Hollings Cancer Center.

Entity Medical University of South Carolina (MUSC - Univ)

Worker Type Employee

Worker Sub-Type Research Grant

Cost Center CC000954 COM BIOCHEM Operations CC

Pay Rate Type Salary

Pay Grade University-00

Pay Range 0.00 - 0.00 - 0.000

Scheduled Weekly Hours 40

Work Shift

The successful candidate will be a highly motivated individual with excellent analytical and communication skills who has an interest in studying therapeutic resistance in cancer. The goal of our research program is to understand the complex signaling networks that regulated resistance to KRAS inhibition. We study the role of oncogenic KRAS in human cancer cells, using diverse methodology, including protein biochemistry, live cell imaging, pharmacological approaches, in vivo models and novel protein biologics as therapeutics.

The position requires the supervision of key laboratory procedures and conducting independent research in conjunction with the Principal Investigator, and to train undergraduate, graduate, medical students, postdocs, and visiting scholars.

Experience with biochemistry and molecular biology techniques and knowledge of reporter assay design and development. Previous experience culturing human cells in vitro and working with animal models of cancer. Demonstrated ability to work independently and in a team; specifically, the candidate must be able to design and execute properly controlled biological experiments independently. Preference will be given to candidates with a background in signal transduction pathways and cancer biology.

Excellent written and verbal communication skills and exceptional time management and a PhD with minimum four years postdoctoral experience is desired.

• Develop and manage multiple scientific projects aimed at understanding the mechanisms of RAS-mediated transformation and tumor development; discovering/developing potential new anti-RAS therapeutics. This includes training and oversight of technical personnel and students to assist in these projects. 35%
• Design and execution of experiments including cell culture assays, molecular biology techniques such as SDS-PAGE, immunoprecipitation and Western blot analysis, DNA cloning and preparation; recombinant protein production and purification; high-throughput screening assays. 35%
• Cooperate with fellow lab members to maintain a clean and functioning lab environment including maintenance of shared equipment and resources. 15%
• Draft manuscripts for publication including primary research articles, reviews, and book chapters. 10%
• Attend and present findings at national and international scientific meetings. 5%

Continuous - 6-8 hours per shift;
Frequent - 2-6 hours per shift;
Infrequent - 0-2 hours per shift. Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist.

(Frequent) Ability to twist at the waist. (Frequent) Ability to perform ’pinching’ operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function.

(Continuous) Ability to lift and carry 30 lbs., unassisted. (Frequent) Ability to lift objects, up to 30 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 30 lbs., from height…