UNIV - Postdoctoral Fellow in Cerebrovascular Pathophysiology - Department of Pathology and Lab
Listed on 2026-08-17
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Research/Development
Research Scientist, Clinical Research, Biomedical Science
Postdoctoral Fellow in Cerebrovascular Pathophysiology in Alzheimer’s Disease and Related Dementias (ADRD) Research
The Department of Pathology and Laboratory Medicine at the Medical University of South Carolina (MUSC) is seeking a highly motivated and talented postdoctoral researcher to join our team part-time. This position focuses on investigating the role of neurovascular unit dysfunction in brain aging and ADRD pathogenesis. In the US alone, 6 million individuals are affected by ADRD. By 2050, this number is expected to rise to 14 million, underscoring the urgent need to develop effective treatments.
The repeated failures of clinical trials targeting amyloid-β (Aβ) peptide, a crucial component in AD pathology, highlight the urgent need to explore other aspects of ADRD. Recent studies have identified cerebrovascular impairment as an early biomarker, significantly influencing the disease's progression and the clinical manifestation of dementia. Despite recognizing this, most research in ADRD focused on neuronal pathologies. The successful candidate will leverage a systems biology approach and cutting‑edge technologies—including cellular and molecular biology techniques, single‑cell RNA sequencing, spatial proteomics, RNAscope, neuropathology, super‑resolution confocal microscopy, and ADRD animal models—to investigate how the neurovascular unit changes in preclinical models.
Details
- Entity:
Medical University of South Carolina (MUSC - Univ) - Worker Type:
Employee - Worker Sub‑Type:
Regular - Cost Center: CC001002 COM PATH Basic Research CC
- Pay Rate Type:
Salary - Pay Grade:
University‑00 - Pay Range: 0.00 - 0.00 - 0.000
- Scheduled Weekly
Hours:
20 - Work Shift:
- 30% — In consultation with the PI, design and execute experiments to advance independent research projects. S/he will be responsible for planning experiments, developing new assays and experimental models as needed, troubleshooting, data analysis and interpretation, and being able to incorporate the results into manuscripts and sections of grant proposals.
- 25% — Perform specific assays including histological procedures, quantitative RT-PCR, immunoblotting, immunofluorescence, confocal microscopy, and flow cytometry assays.
- 30% — Conduct standard animal experiments, including handling transgenic mice and rats, intraperitoneal and tail vein injections, rodent general surgeries (specific surgical procedures can be learned and trained as needed), collecting animal brain tissues, IHC, and data analysis.
- 10% — Assist the PI in training and supervising graduate students, technicians, research assistants and junior lab members.
- 5% — Attend seminars, career development activities locally and nationally at conferences, submit abstracts and present data at local, national & international meetings.
Candidates should have a Ph.D. in neuroscience, molecular cell biology, cellular neurobiology, or any other related field,.
Competitive salary and benefits will be commensurate with qualifications and experience.
Previous experience with AD transgenic models, snRNA-seq, spatial proteomics, and confocal microscopy is highly preferred.
Preferred Experience & Additional Skills- Expert‑level intellectual input to the research objectives and data interpretation of the PI’s projects.
- Ability to work independently in experimental design and project execution.
- Good oral and written communication skills.
- Ability to train and supervise technicians and graduate students.
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Note:
The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors.
(Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching'…
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