UNIV - Post Doctoral Scholar - Department of Neuroscience

Job Description Summary

The Taniguchi Lab investigates how experience-dependent gene expression and epigenetic mechanisms in the brain contribute to long-lasting behavioral plasticity. The postdoctoral scholar will study molecular mechanisms of gene regulation, including DNA hybrid R-loops, chromatin regulation, and transcriptional mechanisms, using molecular, genomic, and behavioral approaches in mouse models.

Medical University of South Carolina (MUSC - Univ)

Employee

Regular

CC000984 COM NEURO RES Operations CC

Salary

University-00

0.00 - 0.00 - 0.000

40

The Taniguchi Lab investigates how experience-dependent gene expression and epigenetic mechanisms in the brain contribute to long-lasting behavioral plasticity. The postdoctoral scholar will study molecular mechanisms of gene regulation, including DNA hybrid R-loops, chromatin regulation, and transcriptional mechanisms, using molecular, genomic, and behavioral approaches in mouse models.

The postdoctoral scholar will design and conduct independent research projects investigating gene expression and epigenetic regulation in the brain. Responsibilities will include experimental design, data collection and analysis, development of molecular and genetic approaches, preparation of manuscripts and grant applications, and collaboration with other laboratory members and investigators.

The Taniguchi Lab investigates how experience-dependent gene expression and epigenetic mechanisms in the brain contribute to long-lasting behavioral plasticity. The postdoctoral scholar will study molecular mechanisms of gene regulation, including DNA hybrid R-loops, chromatin regulation, and transcriptional mechanisms, using molecular, genomic, and behavioral approaches in mouse models.

• 35% Conduct molecular and cellular neuroscience experiments, including gene expression analysis, chromatin assays, molecular cloning, immunohistochemistry, and development of viral constructs for gene and protein manipulation. Perform and optimize experiments using mouse brain tissue and cultured cells.
• 35% Conduct in vivo neuroscience studies, including mouse behavioral experiments, brain tissue collection, stereotaxic surgery, and molecular or genetic manipulation of specific brain regions. Maintain accurate experimental records and troubleshoot experimental procedures.
• 30% Analyze and interpret experimental data, prepare figures, abstracts, manuscripts, and grant applications, and present research findings. Collaborate with other investigators and laboratory members and provide guidance and training to junior researchers and students.

Physical Requirements:

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Note:

The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors.

(Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions.

(Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs., unassisted. (Frequent) Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted.

(Frequent) Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or…