Principal Associate Scientist, DTD

Principal Associate Scientist, Discovery & Translational Development – Solid Biosciences

Charlestown, MA

Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich's ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. We are advancing a diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care.

Patient-focused and founded by those directly impacted by Duchenne, Solid's mission is to improve the daily lives of patients living with devastating rare diseases.

We are seeking a highly skilled and motivated bench scientist to join the Discovery & Translational Development team to support our clinical and pre-clinical programs. The ideal candidate will have a strong scientific background in mammalian cell culture, assay development, and molecular biology. Reporting to the Senior Principal Scientist, Scientific Lead, this is an on-site position based out of Solid's headquarters in Charlestown, MA.

Technical Execution

• Develop AAV functional potency assays by transfecting, transducing, and/or engineering mammalian cell lines
• Develop molecular assays (ddPCR, Protein Simple Jess) and cell-based assays to assess expression cassettes and AAV potency
• Develop ELISA and MSD assays to identify novel biomarkers using patient and nonclinical samples
• Support oversight and review or CRO activities
• Maintenance of electronic lab notebook (ELN) documenting experimental procedures, materials, reagents, and data
• Data Analysis:
  Independently analyze experimental data accurately and efficiently, drawing valid conclusions.
• Lab Maintenance:
  Ensure proper maintenance of laboratory equipment and ensure a safe working environment.

Cross-Functional Support

• Collaborative Projects:
  Participate in projects across different programs, providing expertise where needed.
• Knowledge Sharing:
  Share findings and methodologies with peers to foster a collaborative environment. Provide guidance/mentorship to junior scientists.
• Flexibility:
  Adapt to shifting priorities and contribute to multiple projects as required.

Compliance and Quality Assurance

• Regulatory Compliance:
  Conduct all activities in accordance with regulatory guidelines and company policies.
• Quality Standards:
  Ensure all experimental procedures meet quality standards.
• Documentation:
  Maintain accurate and detailed records of all experiments and results.

Communication

• Reporting:
  Communicate progress and results to scientific leads and team members regularly.
• Team Meetings:
  Participate actively in team meetings, providing updates and insights. Effective communication and interpretation of complex scientific subjects to all audiences.
• Interpersonal
  
  Skills:
  
  Build positive working relationships within the team and across the organization. Apply learnings from the broader organization as they relate to the project team.

• MS in Biology or related discipline with 5+ years of industry experience or BS with 7+ years of industry experience
• Background in Friedreich's ataxia and mitochondrial biology is preferred
• Proficiency with mammalian cell culture, cell line engineering, and/or iPSC differentiation, and experience with transfection or AAV transduction
• Proficient in quantitation of DNA, RNA, and protein expression by ddPCR, qPCR, Protein Simple Jess, ELISA, and MSD
• Software proficiency including Geneious, Snap Gene, NCBI, BLAST, Ensembl, Graph Pad Prism, Benchling, and Microsoft Office Suite
• Ability to work independently and collaboratively
• Strong organizational, written, and verbal communication skills

The base compensation range for this role is: $110,000 – 125,000

Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible…