Sr. Business Systems Manager

COMPANY:

At Bio Cryst, we share a deep commitment to improving the lives of people living with hereditary angioedema (HAE) and other rare diseases. We leverage our expertise in structure-guided drug design to develop first-in-class or best-in-class oral small-molecule and injectable protein therapeutics, led by the efforts of our team of expert scientists in our Discovery Center of Excellence in Birmingham, Alabama.

Our global headquarters is in Durham, North Carolina and our employees span the globe across sites in multiple countries. We are proud of our culture of engagement and accountability that rewards people for innovative thinking and achievement of key objectives. For more information, please visit our website at  or follow us on Linked In and Instagram.

JOB SUMMARY:

The Sr. Business Systems Manager is a technical lead individual contributor and technical Oracle Fusion Cloud SME responsible for maximizing the value, stability, and scalability of Oracle Fusion Cloud ERP, Procurement, HCM, SCM, Supply Planning, and related modules within a regulated life sciences environment. This role provides hands‑on techno‑functional leadership, partnering with Managed Service Providers (MSPs), internal IT peers, and Finance, Procurement, Supply Chain, HR, and Quality stakeholders to successfully deliver enhancements and lead technical work streams.

• Configure, optimize, and enhance Oracle Fusion ERP, Procurement, HCM, SCM and Supply Planning modules.
• Serve as the Oracle technical lead working with teams to build Oracle Fusion integrations with systems like Workday, Veeva, One Stream, and Concur using integration tools such as OIC and Boomi.
• Manage quarterly updates, regression testing cycles, and change-control activities within a GxP-regulated environment.
• Partner with IT, Finance, Supply Chain, HR, Quality and external partners to translate requirements into scalable Oracle solutions.
• Lead complex, cross-functional technical projects, including integrations and system expansions.
• Maintain documentation, SOPs, technical specifications, and audit readiness.
• Govern Fusion security, role-based access, and segregation-of-duties standards.
• Resolve incidents and service requests, conduct root-cause analysis, and implement long-term fixes.
• Monitor system performance, SLAs, KPIs, and user adoption.
• Provide technical leadership on Oracle integrations using OIC, OTBI, BI Publisher, and APIs.
• Maintain proactive, consistent communication with cross-functional business stakeholders.
• Ensure alignment between MSP support activities and business priorities.
• Identify, assess, and prioritize opportunities to improve operational efficiency and business outcomes through technology.
• Lead technical discussions translating business requirements into technical solutions
• Co‑ordinate with teams during UAT cycles to resolve issues
• Support continuous improvement by assessing existing processes and recommending optimizations.
• Manage and deliver small technology projects within the G&A portfolio.
• Ensure strong vendor relationships and oversight of SLAs and support obligations.
• Communicate technology updates and impacts affecting G&A business areas.
• Create functional and design documentation, system standards, and procedures for G&A systems.
• Follow project methodology, SDLC and change control processes to implement solutions
• Ensure compliance with applicable laws, IT controls, regulatory guidelines, and data-governance standards.
• Support audits, security assessments, and compliance activities related to G&A applications and data.
• Support Audit requirements for SOX, CFR Part 11, and IT compliance.
• Able to work flexibly across other technological platforms and cross-functional business areas when required.

• Bachelor's degree or equivalent in Business, Scientific or Technical discipline is required.
• 8 years experience working in related technical field with minimum 3 years of hands‑on experience with Oracle Fusion Cloud, or equivalent combination of education and experience.
• Experience designing and/or managing Oracle Fusion modules including Financials, SCM, Procurement, and HCM.

• Experience…