Research Associate, Brandebura Lab

We are seeking a Postdoctoral Researcher/Research Associate to join Dr. Brandebura's Lab to support our NIH funded research program investigating astrocyte dysfunction in Down Syndrome and Alzheimer's disease. Specifically, we will be focusing on:

• Defining molecular changes that occur within reactive astrocytes in Down Syndrome and Alzheimer's disease.
• Targeting astrocytes to improve neuronal synaptic dysfunction.
• Understanding reactive astrocyte‑microglia and astrocyte‑vascular crosstalk in disorders of the nervous system.

Required skills include animal handling; experience in confocal imaging, immunohistochemistry, western blotting, RNA extraction, and molecular cloning. Desired skills include proteomics, bioinformatic analysis pipelines, and exposure to iPSC differentiation into neuronal and glial cells.

• Conduct full‑time research on astrocyte dysfunction in Down Syndrome and Alzheimer's disease.
• Perform animal handling, confocal imaging, immunohistochemistry, western blotting, RNA extraction, and molecular cloning.
• Apply proteomics, bioinformatics, and iPSC differentiation techniques to study reactive astrocytes.
• Publish and present research findings, contributing to the academic and research career development of the lab.

• Doctoral degree (Ph.D. or equivalent) within the previous five years.

This is an exempt‑level position with benefits. The position is contingent on funding availability, based in Charlottesville, VA, and must be performed fully on‑site.

The University of Virginia is an equal opportunity employer. All interested persons are encouraged to apply, including veterans and individuals with disabilities. Learn more about UVA's commitment to non‑discrimination and equal opportunity employment.