Senior Scientist UVA BAF Core

Main Duties and Responsibilities

The W.M. Keck Biomedical Mass Spectrometry Lab – a part of the Biomolecular Analysis Facility Core at the University of Virginia – seeks a Senior Scientist to expand our work in the areas of proteomics and metabolomics using state‑of‑the‑art instruments to support research within the institution in areas such as basic science research, the Cancer Center, and clinical projects. This position requires expertise and hands‑on experience in biomedical science.

The candidate should have documented expertise in mass spectrometry and chromatography as well as protein and small molecule chemistry. You will support the director through sample preparation, operation/maintenance of advanced mass spectrometers (Orbitrap ‑X – Vanquish Neo and Orbitrap Astral Zoom – Evosep Eno), and data analysis using advanced software packages (Proteome Discoverer, Compound Discoverer, Scaffold, etc). This work will advance institutional goals in proteomic and metabolomic profiling and translational research.

The ideal candidate will have a proven record of excellent communication and team support. You should be highly motivated and able to work independently when designing and executing experiments. The customer support of researchers within the institution is a high priority. Projects will include use of existing techniques to answer current biological challenges and the development of new technologies in proteomics and metabolomics.

• Possess prior experience in qualitative and quantitative proteomics and metabolomics technology and nano‑liquid chromatography and mass spectrometry (LC‑MS; on Orbitrap Fusion, Orbitrap Astral, and/or Orbitrap ‑X).
• The candidate should be familiar with the entire metabolomics and/or proteomics pipeline (including sample preparation, LC and MS operation, and data analysis) and must be able to conduct independent projects.
• Manage multiple projects between multiple laboratories.
• Demonstrate scientific productivity and have excellent oral and written communication skills.
• Demonstrate attention to detail and ability to learn new technologies, flexibility and time management skills.

• Ph.D. in Mass Spectrometry or in a very closely related field with 5+ years’ direct experience in mass spectrometry or a MS in very closely related field and 10+ years’ experience in proteomics or metabolomics.
• Ability to collaborate across multiple disciplines and engage investigators in project design, execution and data analysis.
• Experience in publication and grant writing.
• Experience with Proteome/Compound Discoverer, Scaffold, MS Dial, Metabo Analyst, etc.
• Advanced knowledge of Thermo mass spectrometers – operation and maintenance.