Principal Research Scientist

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, Facebook, Instagram, X and You Tube.

The Translational Safety Pharmacology department provides rigorous in vitro and in vivo safety assessments and fit-for-purpose assay development to enable informed discovery and development decisions. Cardiovascular safety pharmacology is central to advancing safe, high-quality medicines.

The Principal Research Scientist will serve as the in vivo cardiovascular safety pharmacology subject-matter leader, providing scientific and strategic leadership across rodent, canine, and nonhuman-primate models. This role leads the design, execution, interpretation, and reporting of cardiovascular safety studies; advances GLP and regulatory readiness; and partners across a matrixed organization to deliver reproducible, decision-ready data.

• Lead the design, execution, quality, interpretation, and reporting of in vivo cardiovascular safety pharmacology studies across rodent, canine, and nonhuman-primate models.
• Provide scientific leadership for cardiovascular assessments, including hemodynamics, ECG and electrophysiology, pressure-volume loops, echocardiography, vascular reactivity, thrombosis, and relevant disease models.
• Develop, optimize, validate, and implement fit-for-purpose cardiovascular assays and models; author and implement SOPs that support quality, consistency, and regulatory readiness.
• Champion data quality, reproducibility, and scientifically sound interpretation; mentor scientists; communicate study strategy, results, and risk assessments to senior leadership, cross-functional stakeholders, and regulatory-facing teams; and advance cardiovascular safety pharmacology capabilities, workflows, and technologies.
• Manage (directly and indirectly) team members in a matrixed environment to help plan, coordinate, and prioritize studies.

• PhD in physiology, pharmacology, toxicology, or a related field, with 10+ years of relevant experience in cardiovascular biology, safety pharmacology, or a closely related discipline.
• Demonstrated cardiovascular biology and safety pharmacology expertise, including the ability to design, execute, interpret, and report in vivo cardiovascular studies.
• Experience with rodent and large-animal studies, including canine and nonhuman-primate models.
• Experience authoring and implementing SOPs, with working knowledge of GLP, quality systems, and regulatory-ready documentation.
• Strong written and verbal scientific communication skills; demonstrated ability to lead in a matrixed environment, apply critical thinking, troubleshoot complex study issues, and manage multiple priorities effectively.
• At least one year of previous people management experience

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range.
  
  This range may be modified in…