Senior​/Principal Scientist, Medicinal Chemistry – Peptide Drug Design

# Senior/Principal Scientist, Medicinal Chemistry – Peptide Drug Design United States
35 minutes agoID 4369589

Price on request## Details

Employment type:

Full-time Remote:
Yes Company:
Newbridge## Description Got it — here's a version with Our Client written out and ready to drop your client's name/branding in. Just replace [Our Client] and the bracketed details.  Senior/Principal Scientist, Medicinal Chemistry – Peptide Drug Design  Level: Senior Scientist to Associate Director | Byte Dance 3-1 / 3-2 Equivalent

Location:

Flexible – United States or China  About Our Client  Our Client is a clinical-stage biotech company redefining peptide therapeutics through the integration of AI-driven design, novel chemistry, and translational biology. Backed by [top-tier investors/partners], we are advancing a pipeline of First-in-Class (FIC) programs targeting [oncology, metabolic, immunology — insert TAs] with high unmet need.  We combine the scientific rigor of Big Pharma with the speed and ownership of a startup.

Our team is distributed across the US and China, united by one goal: deliver breakthrough medicines to patients, faster.  

The Role  We are seeking a Senior or Principal Scientist / Associate Director in Medicinal Chemistry to lead peptide drug discovery from concept to candidate. You will own the chemistry strategy for FIC programs and work shoulder-to-shoulder with computational, biology, and translational teams to compress timelines from idea to IND.  What You'll Own    
• Lead design and optimization of First-in-Class peptide therapeutics against novel, high-value targets    
• Drive SAR campaigns across macrocycles, stapled peptides, peptide-drug conjugates, and oral bioavailable peptides    
• Partner with AI/ML, CADD, structural biology, DMPK, and pharmacology to run rapid design-make-test cycles    
• Advance programs through hit-to-lead, lead optimization, and IND-enabling studies    
• Represent Medicinal Chemistry on core project teams and mentor junior scientists    What You Bring    
• PhD in Organic Chemistry, Medicinal Chemistry, Chemical Biology, or related field    
• 8+ years industry experience at major U.S. pharmaceutical companies , with peptides/proteins taken to IND/clinic    
• Startup experience :
Thrive in agile, ambiguous environments with high ownership and urgency    
• Byte Dance Level 3-1 to 3-2 equivalent — Senior Scientist, Principal Scientist, or Associate Director scope    
• Deep expertise in peptide design: non-canonical amino acids, cyclization, conjugation, SBDD, and peptide property optimization    
• Proven FIC track record :
Invented novel mechanisms of action and advanced them into development    Why Join Our Client    
• Real shots on goal :
Work on FIC programs with line of sight to patients    
• Speed + Resources :
Startup velocity, backed to move programs to the clinic    
• Global + Flexible :
Base in US or China, collaborate with world-class talent    
• Top-tier package :
Competitive comp, significant equity, and comprehensive benefits    Originally posted on Himalayas    Source:
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