Senior Biostatistician

## Senior Biostatistician Apply:
Onsite:
Chicago, IL:
Full time:
Posted Today:
JR35789
** Department
* * BSD SUR - Research Services
** About the Department
** Operating since 1927 on a strong foundation of multidisciplinary clinical and academic excellence, the University of Chicago Department of Surgery's mission is to meet the most challenging and complex health problems on both a local and global scale. Many of our faculty members are known for their contributions to the advancement of groundbreaking surgical procedures and techniques, including minimally invasive surgery.

In addition to our department's clinical work, our scientists pursue a diverse range of basic, translational, and clinical research projects, including studies on the gut microbiome, tissue bioengineering, stem cell research, cancer, and immunotolerance. This ongoing work and achievement would not be possible without the cohesive effort and commitment of the faculty and staff. We are looking for high energy, collaborative individuals who share our commitment to improving the health of patients in the community and beyond.
** Job Summary
** The Department of Surgery seeks a collaborative Senior Biostatistician to join its research enterprise. The Biostatistician will provide statistical design, analysis, and interpretation support for surgical clinical trials, outcomes research, quality improvement studies, and translational and health services research. The Biostatistician will develop objectives, designing sampling, randomization, and data collection procedures. Develops and implements new innovative procedures in the areas of data collection, quality control, statistical analyses, and presentation of results.

The role partners closely with surgeons, physician scientists and data scientists to advance rigorous, publishable, and externally funded research, and contributes to a culture of methodological excellence within the department.
** Responsibilities
* * Study Design and Grant Support:
* Consult with investigators on study design, hypothesis development, endpoint selection, and sample size and power calculations.
* Write statistical sections of grant proposals (NIH, PCORI, AHRQ, DoD, foundation, and industry), including analysis plans and power justifications.
* Contribute to protocol development, statistical analysis plans (SAPs), and IRB submissions.
* Provide input on randomization schemes, adaptive designs, and pragmatic and stepped-wedge trial designs.

Data Management and Analysis:  
* Perform statistical analyses for prospective and retrospective studies using appropriate methods, including regression modeling, survival analysis, mixed-effects and longitudinal models, propensity score methods, and causal inference approaches.
* Analyze data from clinical registries and large databases (e.g., NSQIP, NCDB, SEER, institutional EHR data, and administrative claims).
* Work with data engineers and research informatics teams to extract, clean, validate, and curate datasets from the electronic health record and REDCap.
* Maintain reproducible, well-documented code and analysis workflows with version control.

Clinical Trial and Regulatory Support:  
* Serve as the study statistician for investigator-initiated trials, including preparing interim and final analyses.
* Ensure analyses comply with applicable regulatory and institutional standards (ICH-GCP, FDA guidance, HIPAA).Scholarship and Dissemination:  
* Draft the methods and results sections of manuscripts, abstracts, and presentations, and respond to statistical reviewer comments.
* Create clear tables, figures, and visualizations for publication and presentation.
* Co-author peer-reviewed publications and qualify for authorship in accordance with ICMJE criteria.

Education and

Collaboration:

* Lead or contribute to departmental research workshops, journal clubs, and methods seminars.
* Collaborate with the institution's biostatistics, epidemiology, and data science cores.

Other Responsibilities:

* Collaborates with researchers in designing, conducting, and publishing results from research projects and assumes primary responsibility for writing statistical design, methods, and analysis for research proposals.
* Designs tables and statistical procedures for specific research studies. Takes primary responsibility for writing the statistical design and documenting statistical considerations in grant proposals for faculty throughout the unit.
* May serve on committees, supervise project personnel, and coordinate quality…