Senior Software Engineer

Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real‑world evidence to deliver real‑time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.

We operate in small, autonomous teams where developers, designers, scientists, and product managers collaborate closely. You'll have direct ownership in building solutions that make a meaningful impact in cancer research and treatment. Our agile approach and modern architecture enable us to innovate rapidly while maintaining the highest standards of quality and scalability.

We are seeking a highly motivated and capable Senior Software Engineer to help advance our Diagnostics initiatives. In this role, you will lead the analysis and design of complex technical problems, architect robust systems, and mentor emerging talent. This position requires deep expertise in full‑stack engineering, relational data systems, bioinformatic workflow orchestration, and algorithmic development. As a senior technical leader, you will be expected to craft high‑quality code, scale genomic data processing pipelines, leverage modern AI tooling, integrate APIs into user‑facing applications, and embed agentic workflows into our core product ecosystem.

• 5+ years of advanced Type Script/JavaScript/python development with a deep understanding of language features and optimization techniques.
• Extensive experience architecting and leading development with Node.js and NestJS frameworks.
• Experience with React development with a demonstrated ability to design and implement complex component systems.
• Proven experience building, scaling, and maintaining bioinformatics orchestration pipelines for high‑throughput genomic data analysis using workflow frameworks such as Nextflow.
• Hands‑on experience managing, monitoring, and optimizing workflow executions via Seqera Platform (Nextflow Tower) across cloud environments.
• Hands‑on experience leveraging GenAI coding tools and autonomous agents (e.g., Copilot, Cursor, LLM APIs) to accelerate development, refactor codebases, and auto‑generate comprehensive unit/integration tests.
• Experience or strong working knowledge of integrating APIs and GenAI technologies into production applications.
• Advanced PostgreSQL skills including query optimization, indexing strategies, and performance tuning.
• Proven expertise implementing sophisticated Redis caching solutions for high‑throughput systems.
• Demonstrated success designing and implementing distributed microservice architectures that seamlessly interface with data‑intensive bioinformatic workflows.
• Significant experience orchestrating infrastructure and applications on GCP, including CI/CD pipelines and cloud‑based compute backends for pipeline execution.
• Mastery of enterprise‑level design patterns and their practical application in large‑scale, mission‑critical systems.

• 7+ years of software development experience with a track record of technical leadership.
• Ability to make high‑impact architectural decisions that balance business needs, data infrastructure constraints, and scientific computing requirements.
• Track record of bridging the gap between software engineering and computational biology/bioinformatics teams to streamline workflow execution and data delivery.
• Enthusiasm for championing AI‑assisted development practices, driving adoption of agentic workflows, and mentoring teams through the evolving landscape of AI tools.
• History of…