Post Doc Fellow, Division of Hematology & Oncology, College of Medicine

Job Overview

As one of the oldest medical schools in the country, the University of Cincinnati College of Medicine (COM) has a reputation for training best-in-class health care professionals and developing cutting-edge procedures and research that improves the health and clinical care of patients. In partnership with the UC Health academic healthcare system and Cincinnati Children’s Hospital Medical Center, College of Medicine’s faculty and providers are transforming the world of medicine every day.

The Department of Internal Medicine, Division of Hematology Oncology is recruiting for a Postdoctoral fellow to work in Dr. Sarah Skuli’s Lab. The Skuli Lab is a basic/translational laboratory with a goal of developing new therapeutic strategies for patients with myeloid malignancies [acute myeloid leukemia (AML), myelodysplastic syndrome (MDS)], particularly those with mutations in the tumor suppressor, TP53, which currently portends a terminal prognosis.

To achieve this goal, we aim to understand the molecular/cellular biology and mechanisms of therapy resistance of TP53 mutant MDS/AML with a particular focus on metabolism and the tumor microenvironment.

• Follow established research protocols to perform experiments in the lab.
• Design laboratory experiments in coordination with the PI. Understand the scientific principles involved in the research and use those principles to troubleshoot and adjust the protocol as appropriate.
• Maintain accurate and detailed records of all laboratory work and experiments.
• Interpret data and judged validity of data.
• Perform statistical and graphical analysis of data.
• Operate standard laboratory equipment. Troubleshoot and correct erroneous results/problems with laboratory equipment and procedures.
• Maintains optimal protocol and assay accuracy by conducting regular quality checks. Provides appropriate safety monitoring checks as assigned.
• May assist in training other post-doctoral fellows, graduate students and junior laboratory personnel in laboratory techniques and equipment.
• Willing and able to assist in daily operations of the laboratory including organization and cleanliness.
• Maintain an active role in laboratory meetings, presentations, publications, which includes contributing material for publications, abstracts and reports.
• Be willing to perform mouse-based in vivo experiments.

Doctoral Degree in the appropriate field or discipline, or the recognized terminal degree.

Experience with routine wet-lab techniques including mammalian cell culture, molecular biology assays (DNA/RNA/protein extraction/quantification, PCR, qPCR, western blotting, cloning/bacterial transformation), flow cytometry/cell sorting, colorimetric/fluorometric assays, Seahorse, and basic data analysis (Excel/Graph Pad).

Experience analyzing bulk and single-cell RNA sequencing data. Familiarity with multi-omics datasets, including metabolomics/lipidomics/proteomics, and use of bioinformatics or statistical tools (i.e. R, Python, Seurat, DESeq2, etc) to integrate and interpret complex datasets.

• Office environment/no specific unusual physical or environmental demands.

Salary/Hourly Pay Rate Information: [[]]

UC offers an exceptional benefits package designed to support your well-being, financial security, and work-life balance. Highlights include:

• Competitive salary based on experience
• Comprehensive health coverage (medical, dental, vision, prescription)
• Flexible spending accounts & wellness programs
• Professional development & mentorship opportunities

Equal Opportunity Employer. Building a workplace where all qualified applicants will receive consideration for employment, including Individuals with Disabilities and Protected Veterans.