Postdoctoral Research Fellow - Xiyuan Guo Regenerative neurobiology

Overview

Primary

Location:

Location S

Department: DB - Guo

Shift: Day (United States of America)

Schedule: Full time

Weekly

Hours:

40

FTE: 1

Employee Status: Regular

The Guo Laboratory is seeking a highly motivated, talented, and creative Postdoctoral Research Fellow to join our dynamic multi-disciplinary team. Our research sits at the cutting edge of regenerative medicine and neurobiology, utilizing state-of-the-art human induced pluripotent stem cell (hiPSC) models, 3D tissue engineering, and advanced multi-omic / bioinformatics integrations to model and dissect human diseases.

Our lab focuses heavily on inventing and refining Next Approach Methodologies (NAMs)—specifically, brain organoids, Blood-Brain Barrier (BBB) assembloids and spinal cord/motor neuron models—to investigate the molecular and epitranscriptomic mechanisms driving neurodegenerative conditions like Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s Disease (AD), as well as neurodevelopmental conditions including autism and Fragile X Syndrome (FXS). The Guo Lab is exceptionally well-funded through major federal agencies and foundation awards—including NINDS, NIMH, NIDA, NIA, and the NSF—and regularly publishes in high-impact journals such as Nature, Cell Stem Cell, Nature Neuroscience, Nature Communications, Science Advances, Molecular Psychiatry, Advanced Science, The Journal of Clinical Investigation, Cell Discovery, and Protein & Cell.

This position offers an unparalleled opportunity to spearhead high-profile projects, leverage robust resources, and work within a deeply collaborative, state-of-the-art academic ecosystem.

• Advanced Cellular Engineering:
  Lead the directed differentiation of hiPSCs into highly enriched neural and vascular lineages (e.g., cortical neurons, motor neurons, astrocytes, microglia, brain endothelial cells, pericytes) to construct complex 3D assembloids and organ-on-a-chip platforms.
• Mechanistic Dissection:
  Deploy CRISPR/Cas9 genome editing, shRNA/ASO tools, and pharmacological screens to interrogate pathological cellular axes.
• Multimodal Analytics:
  Perform and integrate high-resolution functional readouts, including whole-cell patch-clamp electrophysiology, quantitative confocal/super-resolution microscopy, and bulk/single-cell RNA sequencing (scRNA-seq).
• Scientific Leadership:
  Independently manage project milestones, draft high-impact manuscripts, present findings at premier international conferences, and mentor graduate and undergraduate students within a supportive lab ecosystem.

• Fully Funded Positions:
  Competitive salary commensurate with experience, fully aligned with or exceeding NIH postdoctoral stipends, along with a comprehensive institutional benefits package.
• State-of-the-Art Facilities:
  Access to a brand-new, modern laboratory space equipped with dedicated stem cell suites, high-resolution imaging cores, and advanced electrophysiology rigs.
• Career Development:
  Mentorship personalized to your long-term career milestones (whether aiming for a tenure-track academic faculty position or an industry R&D leadership role), with active support for independent fellowship/grant writing (e.g., NIH K99/R00).
• Vibrant Culture: A welcoming, inclusive, and collaborative lab culture where scientific creativity is encouraged and work-life balance is highly respected.

• Develop the skills and knowledge (critical thinking and analysis of data, devising specific aims, long-term project planning and experimental design) to become an independent scientist
• Design, execute, and record laboratory experiments, and analyze data, which may affect decisions regarding future patient care.
• Research and improve current methods and evaluate innovative techniques, protocol and assay accuracy by conducting regular quality and reproducibility checks. Implement this knowledge in the Division/Department. Troubleshoot and correct erroneous results or problems with laboratory equipment.
• Discuss relevant insights about experimental results with Faculty and provide useful recommendations and analysis.
• Present research at laboratory meetings, journal clubs, seminars, and meetings.…