Post Doc Fellow, Division of Hematology & Oncology, College of Medicine

Post Doc Fellow, Division of Hematology & Oncology, College of Medicine

The University of Cincinnati College of Medicine, in partnership with the UC Health academic healthcare system and Cincinnati Children's Hospital Medical Center, is recruiting for a postdoctoral fellow to work in Dr. Sarah Skuli's Lab. The Skuli Lab focuses on developing new therapeutic strategies for patients with myeloid malignancies, particularly those with mutations in the tumor suppressor, TP53. The lab aims to understand the molecular/cellular biology and mechanisms of therapy resistance of TP53 mutant MDS/AML with a particular focus on metabolism and the tumor microenvironment.

Essential Functions:

• Follow established research protocols to perform experiments in the lab.
• Design laboratory experiments in coordination with the PI.
• Understand the scientific principles involved in the research and use those principles to troubleshoot and adjust the protocol as appropriate.
• Maintain accurate and detailed records of all laboratory work and experiments.
• Interpret data and judge the validity of data.
• Perform statistical and graphical analysis of data.
• Operate standard laboratory equipment.
• Troubleshoot and correct erroneous results/problems with laboratory equipment and procedures.
• Maintains optimal protocol and assay accuracy by conducting regular quality checks.
• Provide appropriate safety monitoring checks as assigned.
• May assist in training other post-doctoral fellows, graduate students and junior laboratory personnel in laboratory techniques and equipment.
• Willing and able to assist in daily operations of the laboratory including organization and cleanliness.
• Maintain an active role in laboratory meetings, presentations, publications, which includes contributing material for publications, abstracts and reports.
• Be willing to perform mouse-based in vivo experiments.

Required

Education:

Doctoral Degree in the appropriate field or discipline, or the recognized terminal degree.

Required Experience:

Experience with routine wet-lab techniques including mammalian cell culture, molecular biology assays (DNA/RNA/protein extraction/quantification, PCR, qPCR, western blotting, cloning/bacterial transformation), flow cytometry/cell sorting, colorimetric/fluorometric assays, Seahorse, and basic data analysis (Excel/Graph Pad).

Additional Qualifications Considered:
Experience analyzing bulk and single-cell RNA sequencing data. Familiarity with multi-omics datasets, including metabolomics/lipidomics/proteomics, and use of bioinformatics or statistical tools (i.e. R, Python, Seurat, DESeq2, etc) to integrate and interpret complex datasets.

Physical Requirements/Work Environment:
Office environment/no specific unusual physical or environmental demands.

Compensation and Benefits: UC offers an exceptional benefits package designed to support your well-being, financial security, and work-life balance. Highlights include comprehensive tuition remission, robust retirement plans, real work-life balance, and additional benefits such as competitive salary, comprehensive health coverage, flexible spending accounts & wellness programs, professional development & mentorship opportunities.