Associate Staff Scientist - Leukemia

The Division of Experimental Hematology and Cancer Biology seeks a motivated Associate Staff Scientist. The goal of our laboratory is to develop better therapies to treat patients with acute myeloid leukemia. Patients with acute myeloid leukemia often have an initial response to therapy; however, the disease often reoccurs, and many patients will succumb to this relapsed disease. Not all AML cells are created equally.

Indeed, a small subset of cells called leukemia stem cells (LSCs) persist throughout treatment and drive disease relapse. Therefore, it is critically important that we develop new therapies to better target LSCs.

The successful candidate will identify, mechanistically dissect, and therapeutically target metabolic vulnerabilities of leukemia stem cells enriched from primary acute myeloid leukemia and patient derived xenograft models. Techniques used in this research include culturing of primary AML specimens, flow cytometry analysis and sorting, sample preparation for mass spectrometry, seahorse analysis and functional LSC assays.

• Conduct Research
  - Design, execute and record laboratory experiments; apply standard scientific/research protocols to experiments, research and improve current methods and evaluate innovative techniques. Design and perform experiments and record data according to research protocol. Independently reproduce, evaluate, research and improve techniques currently used. Adapt new methods to existing procedures and modify current experiments through scientific knowledge and intuition. Maintain accurate and detailed records of all laboratory work and experiments.
  
  Develop, set-up and verify new procedures in the laboratory. Standardize and establish new published procedures; evaluate innovative techniques. Develop new assays and new protocols; design formats. Discuss relevant insights about experimental results with Director and provide useful recommendations and analysis. Troubleshoot and correct erroneous results or problems with laboratory equipment. Maintain and repair equipment; monitor proper use by personnel. Maintain optimal protocol and assay accuracy by conducting regular quality and reproducibility checks.
  
  Demonstrate performance at work, consistency in carrying out instructions, accuracy & attention to detail, achieving expected results & continuous improvement.
• Publish
  - Draft, write and edit scientific reports, papers, journal articles and abstracts. Present at local, national and international scientific meetings.
• Teamwork
  - Train and supervise the work of other laboratory personnel as appropriate. Maintain an integral role in the laboratory's meetings, presentations and publications. Present information on research and laboratory work to others at laboratory meetings, journal clubs and seminars. Demonstrate attendance and punctuality, ability to work independently & display initiative and dedication
• Financial Management
  - Assist in preparing, writing and maintaining fiscal budget. Monitor expenditures and prepare capital expenditure requests. Prepare, approve and initiate check requests; track funding, maintain accurate balance and resolve any discrepancies.
• Leadership
  - May act as a mentor to more junior staff, serve as the contact for resolution of complex issues, provide education, guidance and work direction. May provide input and feedback to managers on hiring decisions, professional development and performance management.

• PhD
• 3+ years of work experience in a related job discipline

Location S

Full time

Day (United States of America)

EH&Can Bio
- Exp Hem

Regular

1

40

Cincinnati Children’s is proud to be an Equal Opportunity Employer committed to creating an environment of dignity and respect for all our employees, patients, and families. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, genetic information, national origin, sexual orientation, gender identity, disability or protected veteran status. EEO/Veteran/Disability