Postdoctoral Research Fellow - Bioinformatics Analyst (Lim

Primary Location

Exploration Avenue

Biomedical Informatics

Day (United States of America)

Full time

40

1

Regular

The Computational Regulatory Genomics Laboratory ((Use the "Apply for this Job" box below).) at the Cincinnati Children's Hospital Medical Center (CCHMC) is seeking a highly motivated Postdoctoral Research Fellow. The primary research focus of the lab is to understand the fundamental mechanisms of gene transcriptional regulation across various biological contexts, including developmental biology, cancer biology, and metabolism. We are specifically interested in enhancer regulation and systems-level understanding of enhancer architectures and functions across diverse biological contexts.

We integrate multi-omics data, including ChIP-seq, ChIP-exo, CUT&RUN, GRO-seq, csRNA-seq, RNA-seq, ATAC-seq, Hi-C, and single-cell technologies, to delineate heterogeneous architectures of transcription factor binding events and chromatin landscapes at high resolution. The lab collaborates with multiple experimental laboratories specialized in metabolism, cancer, and development. The lab’s work has been published in many high-profile journals, including Nature, Cell Metabolism, Molecular Cell, Genes & Development, Circulation, Nature Communications, and the Journal of Clinical Investigation.

• Perform analysis and experiments
  - Design, execute, and record analysis and experiments; apply standard scientific protocols to research, and improve current methods and evaluate innovative techniques. Develop and implement human subject research protocols, vertebrate animal research protocols and design experimental procedures and documentation in accordance with the relevant laws and regulations. Prepare, clean and analyze data. Maintain optimal protocol and accuracy by conducting regular quality and reproducibility checks.
• Communicate results/findings
  - Draft, write, and edit scientific reports, papers, journal articles, and abstracts. Present information on research and department work to others at department meetings, journal clubs, and seminars. Present results and discuss relevant insights with Faculty and provide useful recommendations and analysis.
• Innovate and advance departmental capabilities
  - Independently reproduce, evaluate, research, and improve techniques currently used. Adapt new methods to existing procedures and modify current analysis/experiments through scientific knowledge and intuition. Maintain accurate and detailed records of all analysis and experiments. Develop, set-up, and verify new procedures in the department. Standardize and establish new published procedures; evaluate innovative techniques. Develop new protocols; design formats. Maintain an integral role in the department's meetings, presentations, and publications.
  
  Troubleshoot and correct erroneous results or problems with department software/equipment. Maintain and repair software/equipment; monitor proper use by personnel.
• Financial/Budgeting
  - Assist in preparing grant applications. Assist in preparing, writing, and maintaining fiscal budget. Monitor expenditures and prepare capital expenditure requests. Prepare, approve, and initiate check requests; track funding, maintain accurate balance, and resolve any discrepancies.
• Staff Leadership
  - May provide day-to-day functional leadership for a team or directly manage a minimal number of support staff. Establishes team goals. Gives input into, and performs employee performance reviews. Oversees and guides work assignments. Serves as the functional expert and provides guidance to the team.
• Education and Training
  - May serve as course master and develop new courses at the undergraduate and graduate level, including appropriate plans for evaluating student performance; may deliver lectures as a guest lecturer in courses organized by other faculty. Assist in the training of new employees. Serve as a resource and/or mentor to coworkers. Assist in the development and presentation of department training. Identify training needs and provide necessary coaching.

• Ph.D. in related discipline, MD, or equivalent degree
• Preferred:
  PhD in…