Instructor of Physiology & Biophysics

Case Western Reserve University:
School of Medicine (FAC/RA/RS):
School of Medicine - Main Campus (FAC/RA/RS):
Physiology and Biophysics (FAC/RA/RS) Location

Xin Qi Laboratory, Cleveland, Ohio

Open Date

Apr 20, 2026

Description

The Department of Physiology & Biophysics at Case Western Reserve University School of Medicine seeks a qualified candidate to fill a faculty position at the rank of Instructor (non‑tenure track).

The Instructor will lead and support research projects focused on mitochondrial dysfunction and proteostasis in neurodegenerative diseases, including Parkinson’s disease and ALS, and related disorders. The Instructor will design and execute mechanistic and translational research studies, mentor trainees, assist with laboratory management and contribute to grant writing and manuscript preparation. The position is intended for individuals pursuing an academic research career and provides opportunities to develop independent research projects and apply for external funding.

The Instructor will:

• Design and perform cell and molecular biology experiments to investigate mechanisms of mitochondrial dysfunction, protein aggregation, and neurodegeneration.
• Conduct biochemical and cell biological experiments, including immunoblotting, immunoprecipitation, immunofluorescence microscopy, mitochondrial functional assays, and protein interaction studies.
• Analyze complex datasets, including proteomics, transcriptomics, mitochondrial functional data, chemical compounds and peptide database, and animal behavioral and pathological data.
• Lead research projects, prepare study proposals, and manage project timelines.
• Summarize and present research findings at lab meetings and scientific conferences.
• Prepare manuscripts for publication in peer‑reviewed journals.
• Contribute to grant writing and is expected to apply for extramural funding as PI (e.g. NIH K series/R series or foundation grants).
• Assist the Principal Investigator in laboratory management and collaborative research projects, including industry collaborations and translational research programs.

Qualifications

Applicants must have a Ph.D. in Physiology, Molecular and Cell Biology, Pharmacology, Neuroscience, or a related discipline, and must have completed five years of postdoctoral training. The successful candidate should have demonstrated expertise in high‑throughput screening, proteomics, metabolism, and drug discovery and development. Extensive experience working with animal models and patient‑derived iPSC models relevant to neurodegenerative diseases is required.

The candidate must have a strong record of scholarly achievement, as evidenced by publications in high‑impact, peer‑reviewed journals, and a demonstrated ability to lead research projects independently. In addition, applicants must have three years of experience mentoring graduate and undergraduate students.

The annual starting base salary range for this position is from $75,000 to $85,000. CWRU considers factors such as scope and responsibilities of the position, candidate’s work experience, education/training, key skills, internal peer equity, as well as market and organizational considerations when extending an offer. University employees enjoy a comprehensive benefits package that includes excellent healthcare, retirement plans, tuition assistance, and paid time off.

Equal

Opportunity Employer

Case Western Reserve University is an equal opportunity employer. All applicants are protected under federal and state laws and university policy from discrimination based on race, color, religion, sex, sexual orientation, gender identity or expression, national or ethnic origin, protected veteran status, disability, age and genetic information.

Reasonable Accommodation Statement Reasonable Accommodation Statement: Case Western Reserve University complies with the Americans with Disabilities Act regarding reasonable accommodations for applicants with disabilities.

Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity by phone at  or by email atequity. Determinations as to granting reasonable accommodations for any applicant will be made on a case‑by‑case basis.#J-18808-Ljbffr