Senior Scientific Director, Clinical Development, Advanced Pipeline Unit; APU Respiratory

Overview

Site Name: USA - Pennsylvania - Upper Providence; UK – London – New Oxford Street; USA - Massachusetts - Boston

Posted Date: Feb 16 2026

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, focusing our efforts on accelerating assets that meet patients’ needs and have the highest probability of success.

We’re uniting science, technology, and talent to get ahead of disease together.

About RIIRU: The Respiratory, Immunology and Inflammation Research Unit (RIIRU) was formed in 2024 to identify and advance novel molecular targets with genetic associations to disease. Targets with human genetic evidence supporting their causal role in the intended indication improve clinical success. The remit of RIIRU is to identify novel targets based on human genetics, develop assets for clinical studies, and perform trials through to submission for approvals.

This goal is enabled through strategic external and GSK-internal partnerships.

Note: This career opportunity requires an on-site office presence (minimum of two days a week) at one of GSK’s US (PA or MA) or UK (Stevenage or London HQ) sites.

A Senior Scientific Director, Clinical Development is sought to provide clinical and scientific leadership for potential new, established and emerging indications for assets in clinical development with a strong focus in respiratory disease. You will work with project teams to plan and ensure delivery of clinical research and development activities and establish efficient collaboration throughout all stages of development. You will report to the Vice President, Clinical Research Head, Respiratory.

This role drives GSK’s mission to deliver transformative medicines to patients, ensuring clinical excellence, regulatory compliance, and operational efficiency. The successful candidate will deliver results and inspire teams to achieve exceptional outcomes.

• Lead the clinical development strategy from a drug or program level including accountability for the clinical components of the Target Medicine Profile (TMP) and leadership of the clinical matrix team (CMT). Ensure cohesive and comprehensive clinical development plans (CDP) for product(s) and/or indication(s). Identify transformational opportunities with significant patient benefit.
• Contribute to development of the Integrated Evidence Strategy (IES), including oversight of the CDP and its component clinical trials. Integrate scientific rationale, regulatory requirements, product development plans, and commercial goals to optimize asset indications and programs; provide strategic leadership to align study designs with the IES and CDP.
• Drive ambitious yet achievable clinical development timelines, including decision points, risk and cost analyses, and Go/No Go criteria. Lead evaluation of the probability of technical success (PTRS) of clinical studies/programs and mitigate risk where appropriate.
• Nurture relationships with Commercial, Regulatory, Clinical Operations, Medical Affairs, and Statistics. Serve as a clinical contact for senior management and matrix teams, and interface with external experts (regulators, payors, CROs, investigators).
• Lead clinical development discussions and teams at global regulatory interactions. Contribute to global regulatory submissions/files (e.g., IND, NDA, BLA, MAA) including briefing documents, presentations, and responses to regulatory questions.
• Manage technical and leadership development of Clinical Development staff via direct line management, mentoring and coaching.
• Contribute to strategic initiatives, business development activities including due diligence, and organizational initiatives in Clinical Development; champion innovative methodologies and digital tools, encouraging new ways of working.
• Stay abreast of advancements in…