Principal Scientist; NMR Spectroscopist

Job Summary

GSK has an immediate opening for an NMR spectroscopist in research and development at our site in Collegeville, PA. The position is part of the NMR team accountable for all NMR applications in support of drug discovery and development from lead identification to marketing authorization applications.

The NMR team is responsible for the structural characterization of new chemical entities, synthetic intermediates, impurities, degradants, and the characterization of physical form with solid state NMR. The team also develops NMR methodology for novel applications in biologics and maintains seven NMR instruments ranging from 400 MHz to 700 MHz, including solid state NMR capability, and five walk‑up NMRs for use within Medicinal Chemistry and Process Chemistry groups.

The NMR team sits within a broader, multi‑disciplinary analytical group responsible for structural characterization of small molecule synthetic drugs and biologics such as monoclonal antibodies by mass spectrometry, spectroscopy, and other biophysical techniques, as well as stress testing and forced degradation studies. Our group supports the development of innovative and quality medicines for patients through cutting‑edge analytical science.

The NMR team is accountable for all NMR applications supporting drug discovery and development.

Responsibilities include:

• Structural characterization of new chemical entities, synthetic intermediates, impurities, and degradants.
• Characterization of physical form with solid state NMR.
• Development of NMR methodology for novel biologics applications.
• Maintenance of NMR laboratory hardware and software, including cryoprobes, solid state and low field systems.
• Authoring reports and regulatory dossiers.

Basic Qualifications:

• PhD in NMR spectroscopy or related area (or Master’s degree with equivalent experience).
• Experience with solution phase NMR experiments, including 1D, 2D, and heteronuclear NMR techniques for structural characterization.
• Experience with NMR instrumentation hardware and software, including cryoprobes and solid state NMR.
• Experience building and maintaining a state‑of‑the‑art NMR laboratory.
• Two or more years of experience as primary or contributing author of reports and regulatory dossiers.

Preferred Qualifications:

• ≥ 5 years’ experience in the field (or a Master’s degree with ≥ 10 years).
• Demonstrated expertise in modern NMR pulse sequence programming and AU/macro programming on Bruker spectrometers.
• Experience in structure elucidation software such as ACD for NMR.
• Ability to comply with the requirements of quality, safety and GSK policies and ensure protection of intellectual property.
• Experience solving challenging NMR problems.
• Working knowledge of NMR for structural characterization of biologics such as monoclonal antibodies.
• Working knowledge of low field (benchtop) NMR applications and methodology development.
• Working knowledge of solid state NMR instrumentation and experiments.
• Expertise in automated sample preparation, acquisition, and data analysis.
• Knowledge of closely related scientific disciplines (e.g., mass spectrometry, vibrational spectroscopy, XRPD) and ability to engage in cross‑disciplinary teams.
• Demonstrated ability to integrate scientific data and spectroscopic/spectrometric techniques other than NMR to help determine the structure of analytes.
• Excellent communication skills and teamwork behaviors.
• Experience with the overall drug development process, including regulatory file authoring and GxP requirements.
• Demonstrated knowledge and application of digital, data and analytics principles, tools, and approaches.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under…