Principal Scientist - Translational Science - Neurodegeneration

Site Name: USA - Pennsylvania - Upper Providence

Posted Date: Jan 30 2026

As Principal Scientist in the Translational Unit within the Translational and Development Sciences (TDS) team, you will play a critical role in bridging preclinical target and asset validation and early clinical proof of concept studies by designing and performing translational assays in human-derived cells, tissues, biofluids, and surgical discard organs.

This is a lab-based bench scientist position located at the GSK - Upper Providence, Pennsylvania (USA) site.

This role will provide you the opportunity to lead key activities to progress your career, these responsibilities include some of the following...

• Design, execute, and analyze laboratory experiments to advance scientific understanding and support drug discovery.
• Apply hands-on expertise in several of the following capabilities: ELISA/MSD/Quanterix, Western/JESS, flow cytometry, gene expression analysis, iPSC cell culture, and emerging technologies.
• Maintain accurate and detailed laboratory records in alignment with data integrity expectations and ensure compliance with all relevant protocols and safety guidelines.
• Effectively trouble-shoot assays and, when necessary, develop alternative approaches.
• Work closely with preclinical statistics and other relevant teams to ensure robust study design of experiments.
• Present findings to internal teams, stakeholders, and governance in a balanced, clear, and precise manner.
• Work closely with key partners to design, optimize, and execute studies to strengthen target-disease hypotheses and provide evidence for GSK translational pillars by using human ex vivo samples.
• Provide technical and disease input into the translational strategy for one or more projects and influence project direction through interpretation and integration of relevant project and other data.
• Utilize a growing internal and external network to build translational expertise in technology and disease areas; act as a go-to expert on specific technologies and/or disease mechanisms in neurodegeneration.
• Identify and progress collaborations with external partners, including academic institutions and contract research organizations, to leverage expertise and resources to support translational studies.
• Stay up to date with the latest scientific literature and emerging technologies relevant to translational research.
• Ensure compliance with all applicable laws, regulations, and ethical standards in the conduct of translational research.
• Foster a culture of innovation, collaboration, and continuous learning within the translational research team and across the organization.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• PhD in a relevant scientific discipline (e.g., Neuroscience, Immunology, Molecular Biology, Genetics, or related field).
• 4+ years' experience in translational science, biomarker development, and drug discovery.
• Experience in neurodegeneration disease area.
• Hands-on experience in several of the following technical capabilities: bioassay development and analysis (ELISA/MSD/Quanterix), flow cytometry, DNA and RNA sequencing technologies, iPSC cell culture, and emerging technologies.
• Experience in human systems using cell and molecular biology, bioassays, and analytic methods.
• Experience in neurodegenerative disease mechanisms and pathways and the ability to apply this knowledge to translational research and biomarker development.
• Experience with scientific innovation as evidenced by effective support of drug discovery projects, peer-reviewed publications, conferences, internal reports, technical evidence documents or patents.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Excellent problem-solving skills and ability to critically analyze scientific data.
• Familiarity with bioinformatics tools for the interpretation of large-scale datasets.
• Strong written and verbal communication skills, with the ability to effectively present scientific findings to multidisciplinary internal and external stakeholders in a balanced, clear, and precise manner.
• Proven ability to balance…