Research Associate - Molecular Medicine & Therapeutics

Overview

The Chandler Laboratory is seeking a Research Associate to investigate the molecular mechanisms of alternative splicing in cancer, focusing on the p53 tumor suppressor pathway and cell signaling growth pathways. The successful candidate will contribute to research exploring the links between DNA damage, RNA processing, and tumorigenesis, using a combination of cell culture, in vitro splicing assays, and genetically engineered mouse models.

The Research Associate will participate in planning, design, execution, and management of research projects in a foundational (basic) biological/health science research laboratory.

• Investigate the regulation of alternative splicing in response to genotoxic stress, hypoxia and other tumor stressors.
• Characterize models of splicing regulation and their implications for post-transcriptional regulation.
• Develop and test therapeutic tools to modulate splicing in cancer-related genes.
• Utilize novel delivery systems for RNA therapeutics in vivo.
• Coordinate laboratory activities and work assignments of postdoctoral researchers, graduate and undergraduate students, and laboratory research staff.
• Oversee and coordinate maintenance and testing of laboratory equipment; assist in developing and implementing research methodologies; analyze data; prepare research papers and manuscripts; assist in writing proposals for funding.

Minimum

Education Required:

Bachelor’s Degree or equivalent combination of education and experience.

Required Qualifications:

Bachelor’s Degree or equivalent experience; 3 years of relevant experience with an Associate’s Degree, or 1 year with a Bachelor’s Degree. An MS degree in a relevant scientific discipline is a plus. Experience with RNA processing and splicing assays is highly desirable, and familiarity with animal models (mouse/rat) is preferred. Ability to translate, adapt and apply knowledge in biological/health science research.

Function:
Research and Scholarship
Sub Function:
Research
Career Band: S

Career Level:

S1

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The university is an equal opportunity employer, including veterans and disability.

Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post-offer process.

Thank you for your interest in working at Ohio State.