Senior Scientist, Developability & Preformulation

Why Sarepta? Why Now?

The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.

We're looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.

What Sarepta Offers

At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:

• Physical and Emotional Wellness
• Financial Wellness
• Support for Caregivers

The Importance of the Role

The Early Research and Process Development (ERPD) group is seeking a Senior Scientist with deep expertise in biologics preformulation and develop ability assessment, with a focus on proteins, antibodies, and antibody-oligonucleotide conjugates (AOCs). This individual will be responsible for assessing the develop ability of lead molecules through comprehensive evaluations, including biophysical characterization, forced degradation, and short-term, long-term, and in-use stability studies.

The Opportunity to Make a Difference

• Plan and execute formulation experiments to assess and optimize the stability of key intermediates and final products throughout the manufacturing process.
• Establish develop ability profiles for candidate molecules, incorporating considerations for route-of-administration.
• Identify formulation-relevant critical quality attributes for key intermediates and drug product candidates, and guide the development of stability-indicating assays to monitor them.
• Provide expert guidance on formulation technologies and instrumentation to support informed decision-making.
• Offer product handling guidance to cross-functional teams.
• Prepare and review methods, protocols, and technical reports for regulatory submissions or technology transfer.
• Train and mentor Research Associates in process design, experimental execution, troubleshooting, and data interpretation.

More about You

• Degree in Biochemistry, Biochemical Engineering, Bioengineering, or Chemical Engineering
• Ph.D. with ≥ 4 years of biologics formulation experience, or M.S. with ≥ 9 years.
• Experience with AOCs or antibody-drug conjugates (ADCs) is a plus.
• Proven technical expertise in protein formulation technologies (e.g., Unchained Labs Big Tuna/Big Kahuna/Junior, Sartorius AM  Crossflow, Pendotech 5
  
  TFF, Repligen KR2i, etc.).
• Expertise in stability and analytical assays to monitor product quality, including SEC, RP, CE-SDS, cIEF, DLS, DSF, MALS, and mass spectrometry.
• Experience with high-concentration formulation challenges (e.g., viscosity mitigation strategies, excipient screening, protein-protein interaction understanding)
• Experience applying Design of Experiments (DoE) principles to formulation development is a plus.
• Track record of cross-functional collaboration and providing scientifically informed guidance to internal and external teams.
• Proficiency in statistical or data analysis tools (e.g., JMP, Graph Pad, Sigma Plot) is a plus.
• Prior experience in therapeutic protein discovery or biochemistry research.
• Excellent written and verbal communication skills.

What Now?

We're always looking for solution-oriented, critical thinkers.

So, if you're comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.

This position requires work on site at one of Sarepta's facilities in the United States. The targeted salary range for this position is $118,000 - $147,500 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta's compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.