Cell Delivery and Formulation Scientist

Job Title

Battelle delivers when others can't. We conduct research and development, manage national laboratories, design and manufacture products and deliver critical services for our clients—whether they are a multi-national corporation, a small start-up or a government agency.

We recognize and appreciate the value and contributions of individuals from a wide range of backgrounds and experiences and welcome all qualified individuals to apply.

We are seeking a curious and passionate scientist to lead intracellular delivery and formulation development for a biostabilization platform. In this role, you will design and execute high-throughput screening campaigns, integrate delivery and formulation strategies, and collaborate across a multi-institution team of academic and commercial partners.

This position offers direct ownership of a core technical thrust within a high-impact, federally funded program, providing a unique opportunity to drive meaningful scientific advancement at the intersection of cell biology, bioengineering, and translational research.

As a Cell Delivery and Formulation Scientist, the selected individual will lead and contribute to intracellular delivery and formulation development across a multidisciplinary, federally funded program. Responsibilities may include:

• Develop and optimize intracellular delivery of cargo into multiple mammalian cell types, including parameter development on reference delivery systems
• Design, formulate, and optimize cocktails for cell stabilization and recovery
• Plan and execute high-throughput screening of delivery and formulation conditions using automated liquid handling, plate-based viability and metabolic assays, and flow cytometry
• Define quantitative acceptance criteria; analyze viability, apoptosis, metabolic activity, and recovery data; and drive down-selection of lead conditions
• Coordinate technical execution with academic and commercial partners, including transfer of protocols and materials
• Author technical reports, standard operating procedures, and program deliverables; present results to internal leadership and sponsors
• Integrate delivery and formulation with downstream bioprocessing and support recovery optimization
• Maintain accurate laboratory records and adhere to safety and quality standards

• Ph.D. in Bioengineering, Biomedical Engineering, Mechanical Engineering, Chemical Engineering, Cell or Molecular Biology, Biophysics, Materials Science, or a related field with 0–2 years of experience; or an M.S. with 2+ years of relevant experience
• Demonstrated experience in intracellular delivery or cell membrane permeabilization using one or more physical or non-viral methods (e.g., microfluidic cell squeezing/mechanoporation, electroporation or nucleofection, sonoporation, microinjection, nanoneedle/nanostraw, or comparable techniques)
• Hands-on expertise in mammalian cell culture, including primary cells and cell lines, and sterile technique
• Experience developing and running quantitative cell-based assays (viability, cytotoxicity, apoptosis, metabolic activity) and flow cytometry
• Experience formulating and optimizing biological formulations or protectants, or a strong foundation in formulation science
• Strong data analysis skills with the ability to define and apply acceptance criteria
• Strong analytical, organizational, and written and verbal communication skills; ability to work independently and lead within a multidisciplinary team
• Applicants must have authorization to work in the United States. We are unable to sponsor or take over sponsorship of any employment Visa at this time.

• Experience with cell stabilization technologies such as desiccation, cryopreservation, or lyophilization
• Familiarity with protect ant biology and anhydrobiosis
• Experience with high-throughput screening, automated liquid handling, and design of experiments (DOE)
• Proficiency with data analysis tools (e.g., Graph Pad Prism, R, Python, Flow Jo)
• Track record of peer-reviewed publications or conference proceedings
• Experience with cell and gene therapy products or manufacturing (e.g., CAR-T, stem cell, or other cell-based…