Sr. Scientist, DNA Development

Opportunity for Secondment to Ask Bio

We’re pleased to share an exciting secondment opportunity at Ask Bio.

This role is available for a time period to be determined by leadership at both Bayer and Ask Bio. While most assignments range from one to two years, the exact duration will be based on business needs and mutual agreement.

This secondment offers a unique chance to broaden your experience, expand your knowledge, and contribute meaningfully to Ask Bio’s mission: to advance gene therapy and change the lives of patients around the world.

We look forward to seeing how our colleagues continue to grow and make an impact across the Bayer-Ask Bio partnership.

Pioneering science to create transformative molecular medicines.

Lead innovative science and drive clinical outcomes to transform people’s lives.

• Advance innovative science by pushing boundaries.

• Bring transformative therapeutics to patients in need.

• Provide an environment for employees to reach their fullest potential.

• Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.

• Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.

• Embrace Responsibility. We are humbled by the enormity of our mission.
  
  We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.

• Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.

• Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through.

This strategic role leads independent initiatives to optimize DNA manufacturability, quality, and scalable production. The successful candidate will be accountable for the rational design and technical review of DNA constructs that serve as critical starting material for rAAV manufacturing. This role drives process understanding by linking DNA design to process performance and vector quality while generating summary technical documentation and fostering a collaborative culture of scientific excellence.

This position is based on-site in Research Triangle Park (RTP), North Carolina, and reports to the Process Development Associate Director/Director.

• Independently design and execute project initiatives to improve DNA manufacturability and quality with good judgement against defined timelines

• Rationally design and test DNA constructs to increase DNA and rAAV manufacturing productivity and/or improved DNA and vector quality

• Provide subject matter expertise on development of new and/or improved methodologies for DNA production that is fit for purpose (scale, yield etc)

• Lead Ask Bio CMDO collaborations to improve DNA manufacturing and transfer of relevant processes

• Serve as a technical consultant on DNA starting materials used for Chemistry, Manufacturing and Control (CMC) activities and regulatory strategis, when applicable

• Lead investigations and troubleshooting of DNA purification and analytical characterization as needed

• Represent the DNA Development function in project teams and present data at internal and external forums

• Author technical and development documents, including relevant regulatory submission sections

• Excellent team player who develops and encourages a team environment within the company’s mission and values

• Mentors and develops team members by establishing a collaborative and growth minded culture that encourages personal and professional development

• Perform hands-on experiments, when necessary, while maintaining and promoting a clean, efficient, and safe laboratory environment

• PhD (Molecular Biology, Genetics, Virology or equivalent) with 5+ years of relevant work experience including post-doc experience; or MS (Molecular Biology, Genetics, Virology or equivalent) with 10+ years of relevant work experience

• Expertise in viral gene therapy, including recombinant adeno-associated virus systems

• Strong, comprehensive…