Manager, RNA Facility Core

Job Description:

The RNA Core is a facility core within the National Institute of General Medical Sciences (NIGMS) COBRE:
Center for the RNA Biology in Health and Disease created to provide an integrative suite of RNA biology services and advice to PIs in Rhode Island who are studying RNA while also training the next generation of RNA biologists through courses/workshops.

The Manager of the RNA Core Facility will be instrumental in establishing this core to provide long-read sequencing for identifying new RNA species and mapping RNA modifications both globally and at single-molecule level in sequence context. This central function will include specialized adaptations of sequence based genomic methods such as nascent RNA seq. The Manager will research and develop methodologies for researchers to study diverse aspects of RNA biology.

The RNA core will function as a pass-through service provider with the Manager facilitating sample and data transfer to other COBRE funded cores  this capacity, the RNA Facility Core Manager will implement RNA biology protocols as a “front-end” to services provide by other cores. For example the RNA core will:
1) Identifying RBP occupancy and binding specificity with methods such as RNA immunoprecipitation followed by proteomics for RNA binding protein identification conducted by the Proteomics core,
2) RNA visualization with methods such as RNA FISH probe generation followed by imaging at the Imaging core,
3) RNA functional genomics with methods such as massively parallel reporter assays (MPRAs) followed by sequencing at the Genomics core,
4) experimental design for RNA biophysical and structural analysis in the Structural Biology Core, and
5) facilitating data transfer to the Computational Biology Core.

Additionally, the RNA Core Facility Manager will run a series of summer courses and workshops on RNA biology which will draw participants nationally and locally.

This is a fixed term position with a current end date of 08/30/2030 which may be extended based upon available funding.

Job Qualifications

Education and Experience:

Required:

PhD degree in genetics, genomics or molecular biology or related field plus 4 years relative experience

PhD graduate research experience in genomics and performing long read sequencing on RNA and DNA, ideally including mapping of RNA modifications

Relevant coursework and advanced knowledge of laboratory approaches and techniques in RNA biology

Strong computational biology skills

Programming experience is advantageous

Prior experience mentoring younger researchers as will supervise a technician

Demonstrated qualities of resourcefulness and being pro-active

Experience operating Oxford Nanopore sequencer desired

Job

Competencies:

Flexible availability to maintain and monitor 24/7 operation of Oxford Nanopore sequencer using remote access tools and in person if necessary and fixing problems as they arrive even outside of standard work hours.

Excellent written and communication skills.

Ability to be observant and self-motivated.

Ability to think critically and problem-solve.

Ability to work independently.

Ability to communicate clearly and professionally with core facility users.

Ability to complete accurate records and follow detailed instructions.

CRIMINAL BACKGROUND AND EDUCATION CHECK REQUIRED.Benefits of Working at Brown:

Please review additional information on the Benefits of Working ruiting

Start Date:

Job Posting

Title:

Manager, RNA Facility Core Department:

Department of Molecular Biology, Cell Biology and Biochemistry Grade:

Grade 11

Worker Type:

Employee Worker Sub-Type:

Fixed Term (Fixed Term)
Time Type:

Full time Scheduled Weekly

Hours:

37.5

Position

Work Location:

Onsite Submission Guidelines:

Please note that to be considered for a staff position at Brown University, you must submit a separate application for each position you wish to be considered for. Applications are reviewed only for the specific position to which they are submitted and are not automatically considered for future openings.

This position is not eligible for visa sponsorship.

The designated Position Work Location for each position determines the approved modality of work. Positions are…